Current Issue April 2012, Vol. 86, No. 4

Issue Highlights

Original Articles

Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression
April 2012(Vol. 86 | No. 4 | Pages 141-147)
C.E. Childs, S.P. Hoile, G.C. Burdge, P.C. Calder

A radioenzymatic assay to identify three groups of phospholipase A2 in platelets
April 2012(Vol. 86 | No. 4 | Pages 149-153)
Leda L. Talib, Breno S. Diniz, Isis A. Zainaghi, Orestes V. Forlenza, Wagner F. Gattaz

Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: An analysis of the 2005–2008 National Health and Nutrition Examination Survey
April 2012(Vol. 86 | No. 4 | Pages 155-160)
Claire A. Hoffmire, Robert C. Block, Kelly Thevenet-Morrison, Edwin van Wijngaarden

Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery
14 May 2012
S. Kenchegowda, J. He, H.E.P Bazan
Abstract: Alterations in corneal innervations result in impaired corneal sensation, severe dry eye and damage to the epithelium that may in turn lead to corneal ulcers, melting and perforation. These ...
n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: Effect of rest and neuronal activation in the rat
14 May 2012
Emilie Harbeby, Mélanie Jouin, Jean-Marc Alessandri, Marie-Sylvie Lallemand, Alain Linard, Monique Lavialle, Alain Huertas, Stephen C. Cunnane, Philippe Guesnet
Abstract: n-3 Polyunsaturated fatty acids (PUFA) support whole brain energy metabolism but their impact on neuroenergetics in specific brain areas and during neuronal activation is still poorly unders...
CD36 as a target to prevent cardiac lipotoxicity and insulin resistance
14 May 2012
Jan F.C. Glatz, Yeliz Angin, Laura K.M. Steinbusch, Robert W. Schwenk, Joost J.F.P. Luiken
Abstract: The fatty acid transporter and scavenger receptor CD36 is increasingly being implicated in the pathogenesis of insulin resistance and its progression towards type 2 diabetes and associated c...
Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?
11 May 2012
Stephen C. Cunnane, Raphael Chouinard-Watkins, Christian A. Castellano, Pascale Barberger-Gateau
Abstract: A crossroads has been reached on research into docosahexaenoic acid (DHA) and Alzheimer's disease (AD). On the one hand, several prospective observational studies now clearly indicate a prot...
Determinants of DHA levels in early infancy: Differential effects of breast milk and direct fish oil supplementation
10 May 2012
S.J. Meldrum, N. D'Vaz, Y. Casadio, J.A. Dunstan, N. Niels Krogsgaard-Larsen, K. Simmer, S.L. Prescott
Abstract: Introduction: Although omega (n)-3 long-chain polyunsaturated fatty acids (LCPUFA), particularly docosahexaenoic acid (DHA), intakes are important during infancy, the optimal method of incre...

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About Prostaglandins, Leukotrienes and Essential Fatty Acids

The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes and Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.

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ISSFAL, the International Society for the Study of Fatty Acids and Lipids is an International Scientific Society established in 1991, with more than 500 members from over 40 countries. ISSFAL members are scientists, medical professionals, educators, administrators, communicators and others with an interest in the health effects of dietary fats, oils and lipids; members include researchers carrying out studies on the health effects of omega-3 and omega-6 fatty acids, conjugated linoleic acids (CLA), saturated and monounsaturated fatty acids, as well as other lipids. ISSFAL is the foremost International Scientific Society dealing exclusively with the health impact of dietary lipids.

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Prostaglandins, Leukotrienes and Essential Fatty Acids (YPLEF) is published by Elsevier for the International Society for the Study of Fatty Acids and Lipids.