Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 70, Issue 4 , Pages 377-381 , April 2004

The investigation of cytosolic phospholipase A2 using ELISA

  • Donald J Macdonald

      Affiliations

    • Department of Biochemistry, Victoria Infirmary, Glasgow G42 9TY, Scotland, UK
    • Corresponding Author InformationCorresponding author
    • ,
  • Rose M Boyle

      Affiliations

    • Department of Biochemistry, Victoria Infirmary, Glasgow G42 9TY, Scotland, UK
    • ,
  • Alastair C.A Glen

      Affiliations

    • Department of Biochemistry, Victoria Infirmary, Glasgow G42 9TY, Scotland, UK
    • ,
  • Brian M Ross

      Affiliations

    • The Ness Foundation, Dochfour Business Park, Inverness IV3 8GY, UK
    • ,
  • A.Iain M Glen

      Affiliations

    • The Ness Foundation, Dochfour Business Park, Inverness IV3 8GY, UK
    • ,
  • Pauline E Ward

      Affiliations

    • The Ness Foundation, Dochfour Business Park, Inverness IV3 8GY, UK
    • ,
  • Siofradh B McKinney

      Affiliations

    • The Ness Foundation, Dochfour Business Park, Inverness IV3 8GY, UK
    • ,
  • Myrtle A Peterkin

      Affiliations

    • West of Scotland Blood Transfusion Centre at Gartnavel General Hospital, Glasgow G12 0XB, UK

,Accepted 18 December 2003.

References 

  1. Glen I, Glen EMT, Horrobin DF, et al.  A red cell membrane abnormality in as subgroup of schizophrenic patients (evidence for two diseases). Schizophr. Res. 1994;12:53–61
  2. Peet M, Laugharne JDE, Mellor J, Ramchand CN. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients and the clinical effects of dietary supplementation. Prostaglandins Leukot. Essent. Fatty Acids. 1996;55:71–75
  3. Arvindakshan M, Sitasawad S, Debsikdar V, et al.  Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients. Biol. Psychiatry. 2003;53:56–64
  4. Yao JK, Sherry L, Reddy RD. Membrane phospholipid abnormalities in post-mortem brains from schizophrenic patients. Schizophr. Res. 2000;42:7–17
  5. D.F. Horrobin, The phospholipid concept of psychiatric disorders and its relationship to the neurodevelopmental concept of schizophrenia, in: M. Peet, A.I.M. Glen, D.F. Horrobin (Eds.), Phospholipid Spectrum Disorder in Psychiatry, Marius Press, Carnforth UK, 1999, pp. 3–20.
  6. D.J. Macdonald, R.M. Boyle, A.C.A. Glen, D.F. Horrobin, Cytosolic phospholipase A2 type IVA is present in human red cells, Blood, 2004, in press.
  7. Ross BM, Hudson C, Erlich J, Warsh JJ, Kish SJ. Increased phospholipid breakdown in schizophrenia (evidence for the involvement of a calcium-independent phospholipase A2). Arch. Gen. Psychiatry. 1997;54:487–494
  8. Gattaz WF, Hübner CK, Nevalainen TJ, Thuren T, Kinnunen PKJ. Increased serum phospholipase-A2 activity in schizophrenia (a replication study). Biol. Psychitry. 1990;28:495–501
  9. M. Glen, Family studies in schizophrenia, in: M. Peet, I. Glen, D.F. Horrobin (Eds.), Phospholipid Spectrum Disorder in Psychiatry, Marius Press, Carnforth UK, 1999, pp. 145–156.
  10. Macdonald DJ, Glen ACA, Boyle RM, et al.  An ELISA method for Type IVA cPLA2 in RBC (a potential marker for schizophrenia). Schizophr. Res. 2000;41:259
  11. Alda M, Ahrens B, Lit W, et al.  Age of onset in familial and sporadic schizophrenia. Acta Psychiatr. Scand. 1996;93:447–450
  12. Waldo MC. Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics. Schizophr. Res. 1999;40:49–53
  13. Rintala J, Seemann R, Chandrasekaran K, et al.  85kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain. Mol. Neurosci. 1999;10:3887–3890
  14. Myers CS, Contreras MA, Chang MCJ, Rapoport SI, Appel NM. Haloperidol downregulates phospholipase A2 signalling in rat basal ganglia circuits. Brain Res. 2001;896:96–101

PII: S0952-3278(04)00009-2

doi: 10.1016/j.plefa.2003.12.013

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 70, Issue 4 , Pages 377-381 , April 2004

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