Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 70, Issue 4 , Pages 399-401 , April 2004

The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome

,Accepted 18 December 2003.

References 

  1. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome (a comprehensive approach to its definition and study). Ann. Intern. Med. 1994;121:953–959
  2. Horrobin DF. Essential fatty acids and the post-viral fatigue syndrome. In:  Jenkins R,  Mowbray J editor. Post-viral Fatigue Syndrome. Chichester: Wiley; 1991;p. 393–404
  3. Sands J, Auperin D, Snipes W. Extreme sensitivity of enveloped viruses, including herpes simplex, to long-chain unsaturated monoglycerides and alcohols. Antimicrob. Agents Chemother. 1979;15:67–73
  4. Horowitz B, Piet MP, Prince AM, Edwards CA, Lippin A, Walakovits LA. Inactivation of lipid-enveloped viruses in labile blood derivatives by unsaturated fatty acids. Vox Sang. 1988;54:14–20
  5. Horrobin DF. Phospholipid and fatty acid biochemistry in schizophrenia. In:  Peet M,  Glen I,  Horrobin DF editor. Phospholipid Spectrum Disorders in Psychiatry and Neurology. 2nd edition.. Carnforth, Lancashire: Marius Press; 2003;p. 123–162
  6. Puri BK, Counsell SJ, Zaman R, Main J, Collins AG, Hajnal JV, et al. Relative increase in choline in the occipital cortex in chronic fatigue syndrome. Acta Psychiatr. Scand. 2002;106:224–226
  7. Ruiz-Cabello J, Cohen JS. Phospholipid metabolites as indicators of cancer cell function. NMR Biomed. 1992;5:226–233
  8. Chaudhuri A, Condon BR, Gow JW, Brennan D, Hadley DM. Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome. Neuroreport. 2003;14:225–228
  9. B.K. Puri, J. Holmes, G. Hamilton. Eicosapentaenoic acid (EPA)-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int. J. Clin. Pract., in press.
  10. Behan PO, Behan WMH, Horrobin DF. A placebo-controlled trial of n-3, n-6, essential fatty acids in the treatment of postviral fatigue syndrome. Acta. Neurol. Scand. 1990;82:209–216
  11. Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome (a case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA). Acta. Neurol. Scand. 1999;99:112–116

PII: S0952-3278(04)00012-2

doi: 10.1016/j.plefa.2003.12.015

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 70, Issue 4 , Pages 399-401 , April 2004

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