Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a ³¹P magnetic resonance spectroscopy study

Abstract 

There is biochemical evidence to suggest that membrane phospholipid metabolism may be impaired in some patients with schizophrenia. The aim of this study was to test the hypothesis that patients with schizophrenia who have violently offended while psychotic suffer from changes in cerebral phospholipid metabolism. Cerebral 31-phosphorus magnetic resonance spectroscopy was carried out in 15 male patients with schizophrenia who had violently offended (homicide, attempted murder, or wounding with intent to cause grievous bodily harm) while psychotic and in a control group of 13 age-matched healthy male control subjects. Spectra were obtained from 70×70×70mm³ voxels in the brain using an image-selected in vivo spectroscopy pulse sequence. βNTP was lower (P<0.04) and γNTP was higher (P<0.04) in the patient group compared with the normal control group. Our results are suggestive of increased cerebral energy metabolism taking place in the forensic patients.