Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 70, Issue 4 , Pages 409-411 , April 2004

Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study

  • B.K Puri

      Affiliations

    • MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    • ,
  • S.J Counsell

      Affiliations

    • MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    • ,
  • G Hamilton

      Affiliations

    • MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    • ,
  • M.G Bustos

      Affiliations

    • Three Bridges Medium Secure Unit, West London Mental Health NHS Trust, Uxbridge Road, Middlesex UB1 3EU, UK
    • Imperial College School of Medicine, St Mary's Campus, London, UK
    • ,
  • D.F Horrobin

      Affiliations

    • Laxdale Research, Kings Park House, Laurelhill Business Park, Stirling, Scotland FK7 9JQ, UK
    • Deceased.
    • ,
  • A.J Richardson

      Affiliations

    • Mansfield College, University of Oxford, Oxford OX1 3TF, UK
    • University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    • ,
  • I.H Treasaden

      Affiliations

    • Three Bridges Medium Secure Unit, West London Mental Health NHS Trust, Uxbridge Road, Middlesex UB1 3EU, UK
    • Imperial College School of Medicine, St Mary's Campus, London, UK
    • Corresponding Author InformationCorresponding author. Three Bridges Medium Secure Unit, West London Mental Health NHS Trust, Uxbridge Road, London UB1 3EU, UK. Tel.: +44-20-8354-8086; fax: +44-20-8571-9796

,Accepted 18 December 2003.

References 

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  2. Yao JK, Van Kammen DP, Welker JA. Red blood cell membrane dynamics in schizophrenia. II. Fatty acid composition. Schizophr. Res. 1994;13:217–226
  3. Yao JK, Van Kammen DP, Gurklis J. Red blood cell membrane dynamics in schizophrenia. III. Correlation of fatty acid abnormalities with clinical measures. Schizophr. Res. 1994;13:227–232
  4. Peet M, Laugharne J, Rangarajan N, Horrobin D, Reynolds G. Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients. J. Psychiatr. Res. 1995;29:227–232
  5. Gattaz WF, Kollisch M, Thuren T, Virtanen JA, Kinnunen PK. Increased plasma phospholipase-A2 activity in schizophrenic patients. Reduction after neuroleptic therapy. Biol. Psychiatry. 1987;22:421–426
  6. Gattaz WF, Hubner CV, Nevalainen TJ, Thuren T, Kinnunen PK. Increased serum phospholipase A2 activity in schizophrenia (a replication study). Biol. Psychiatry. 1990;28:495–501
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  8. Ward PE, Sutherland J, Glen EM, Glen AI. Niacin skin flush in schizophrenia (a preliminary report). Schizophr. Res. 1998;29:269–274
  9. Puri BK, Hirsch SR, Easton T, Richardson AJ. A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2002;26:49–52
  10. Horrobin DF, Glen AI, Vaddadi K. The membrane hypothesis of schizophrenia. Schizophr. Res. 1994;13:195–207
  11. Corrigan F, Gray R, Strathdee A, Skinner R, Van Rhijn A, Horrobin D. Fatty acid analysis of blood from violent offenders. J. Forensic. Psychiatry. 1994;5:83–91
  12. Vanhamme L, Van Den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J. Magn. Reson. 1997;129:35–43
  13. Naressi A, Couturier C, Devos JM, Janssen M, Mangeat C, de Beer R, et al. Java-based graphical user interface for the MRUI quantitation package. J. Magn. Magn. Mater. 2001;12:141–152
  14. Cox IJ. Development and applications of in vivo clinical magnetic resonance spectroscopy. Prog. Biophys. Mol. Biol. 1996;65:45–81
  15. Fukuzako H. Neurochemical investigation of the schizophrenic brain by in vivo phosphorus magnetic resonance spectroscopy. World J. Biol. Psychiatry. 2001;2:70–82

PII: S0952-3278(04)00014-6

doi: 10.1016/j.plefa.2003.12.017

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 70, Issue 4 , Pages 409-411 , April 2004

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