Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 77, Issue 1 , Pages 21-28, July 2007

Effect of Chia oil (Salvia Hispanica) rich in ω-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma☆

  • C.E. Espada

      Affiliations

    • Iª Cátedra de Biología Celular, Histología y Embriología, Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. Ciudad Universitaria. Casilla de Correos 220, 5000, Córdoba. Argentina
    • ,
  • M.A. Berra

      Affiliations

    • Iª Cátedra de Biología Celular, Histología y Embriología, Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. Ciudad Universitaria. Casilla de Correos 220, 5000, Córdoba. Argentina
    • ,
  • M.J. Martinez

      Affiliations

    • Laboratorio de Calidad de Granos. EEA-INTA Manfredi. Ruta Nac. 9km 636. Córdoba, Argentina
    • ,
  • A.R. Eynard

      Affiliations

    • Iª Cátedra de Biología Celular, Histología y Embriología, Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. Ciudad Universitaria. Casilla de Correos 220, 5000, Córdoba. Argentina
    • ,
  • M.E. Pasqualini

      Affiliations

    • Iª Cátedra de Biología Celular, Histología y Embriología, Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. Ciudad Universitaria. Casilla de Correos 220, 5000, Córdoba. Argentina
    • Corresponding Author InformationCorresponding author. Tel.: +543514334020; fax: +543514810404.

Received 16 February 2007; received in revised form 11 May 2007; accepted 22 May 2007. published online 09 July 2007.

Abstract 

We investigated the effects of certain dietary polyunsaturated fatty acids (PUFAs) and related eicosanoids on the growth and metastasis formation of a murine mammary gland adenocarcinoma. Salvia hispanica (ChO) and Carthamus tinctorius (SaO) vegetable oil sources of ω-3 and -6 PUFAs and a commercial diet as control (CO), were used. We analysed fatty acids of neoplastic cells (NC) membranes by GLC; the eicosanoids 12- HETE and 12-HHT (LOX and COX metabolites) by HPLC and apoptosis and T-lymphocyte infiltration by flow cytometry and microscopy. NC from ChO groups showed lower levels of arachidonic acid and of both eicosanoids compared to SaO and CO (p<0.05). The ChO diet decreased the tumor weight and metastasis number (p<0.05). Apoptosis and T-lymphocyte infiltration were higher and mitosis decreased with respect to the other diets (p<0.05). Present data showed that ChO, an ancient and almost unknown source of ω-3, inhibits growth and metastasis in this tumor model.

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☆ This work was supported by Grants from CONICET, FONCYT, AGENCIA CÓRDOBA CIENCIA, SECYT and Fundación para el Progreso de la Medicina de la Ciudad de Córdoba (Argentina).

PII: S0952-3278(07)00071-3

doi:10.1016/j.plefa.2007.05.005

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 77, Issue 1 , Pages 21-28, July 2007

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