Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 77, Issue 1 , Pages 37-43 , July 2007

Apoptosis is mediated by cytosolic phospholipase A2 during simulated ischaemia/reperfusion-induced injury in neonatal cardiac myocytes

Received 11 April 2007 ,Accepted 17 June 2007.

References 

  1. Gill C, Mestril R, Samali A. Losing heart; the role of apoptosis in heart disease—a novel therapeutic target?. FASEB J. 2002;16:135–146
  2. Olivetti G, Abbi R, Quaini F, et al. Apoptosis in the failing human heart. N. Engl. J. Med. 1997;336:1131–1141
  3. Narula J, Haider N, Virmani R, et al. Programmed myocyte death in end-stage heart failure. N. Eng. J. Med. 1996;335:1182–1189
  4. Saraste A, Pulkki K, Kallajoki M, Hendriksen K, Parvinen M, Viopoi-Pulkki L-M. Apoptosis in human acute myocardial infarction. Circulation. 1997;95:320–323
  5. Kajstura JW, Cheng W, Reiss K, et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab. Invest. 1996;79:949–956
  6. Balsinde J, Balboa MA, Insel PA, Dennis EA. Regulation and inhibition of phospholipase A2. Annu. Rev. Pharmacol. Toxicol. 1999;39:175–189
  7. Lambeau G, Lazdunski M. Receptors for a growing family of secreted phospholipase A2. Trends Pharmacol. Sci. 1999;20:162–170
  8. Clark JD, Lin LL, Kriz RW, et al. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell. 1991;65:1043–1051
  9. Song C, Chang XJ, Bean KM, Proia MS, Knopf JL, Kriz RW. Molecular characterization of cytosolic phospholipase A2-beta. J. Biol. Chem. 1999;274:17063–17067
  10. Tang J, Kriz RW, Wolfman N, Shaffer M, Seehra J, Jones SS. A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs. J. Biol. Chem. 1997;272:8567–8575
  11. Underwood KW, Song C, Kriz RW, Chang XJ, Knopf JL, Lin LL. A novel calcium-independent phospholipase A2, cPLA2-gamma that is prenylated and contains homology to cPLA2. J. Biol. Chem. 1998;273:21926–21932
  12. Huang Z, Payette P, Abdullah K, Cromlish WA, Kennedy BP. Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. Biochemistry. 1996;26:3712–3721
  13. Gijon MA, Leslie CC. Regulation of arachidonic acid release and cytosolic phospholipase A2 activation. J. Leukocyte Biol. 1999;65:330–336
  14. Pinson A, Tirosh R, Tremblover V, Shohami E. Oxygen deprivation and reoxygenation augment prostacyclin synthesis in cultured ventricular myocytes. Prostaglandins Leukotr. Essent. Fatty Acids. 1996;54:211–215
  15. Engelbrecht AM, Niesler C, Page C, Lochner A. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Basic Res. Cardiol. 2004;99:338–350
  16. Gomez LA, Alekseev AE, Aleksandrova LA, Brady PA, Terzic A. Use of MTT assay in adult ventricular cardiomyocytes to assess viability: effects of adenosine and potassium on cellular survival. Mol. Cell Cardiol. 1997;29:1255–1266
  17. Bradford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976;71:248–254
  18. Ilic D, Eduardo AC, Schlaepfer DD, Dazin P, Aizawa S, Damsky CH. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J. Cell Biol. 1998;143:547–560
  19. Nemenhoff RA, Winitz S, Qian N-X, Van Putten V, Johnson GL, Heasly LE. Phosphorylation and activation of a high molecular weight form of phospholipase A2 by 42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem. 1993;268:1960–1964
  20. Leslie CC. Properties and regulation of cytosolic phospholipase A2. J. Biol. Chem. 1997;272:16907–16912
  21. Aimond F, Rauzier JM, Vassort G. Simultaneous activation of p38 MAPK and p42/44 MAPK by ATP stimulation of the K+ current ITREK in cardiomyocytes. J. Biol. Chem. 2000;275:39110–39116
  22. Leslie CC. Properties and regulation of cytosolic phospholipase A2. J. Biol. Chem. 1997;272:16712–16907
  23. Mackay K, Mochly-Rosen D. Involvement of p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia. J. Mol. Cell Cardiol. 2000;32:1585–1588
  24. Abe J-I, Baines CP, Berk BC. Role of mitogen-activated protein kinases in ischemia and reperfusion injury. Circ. Res. 2000;86:607–609
  25. Yue T-L, Wang C, Gu J-L, et al. Inhibition of extracellular signal-regulated kinase enhances ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circ. Res. 2000;86:692–699
  26. Takai S, Haruhiko T, Yoshida M, et al. Prostaglandin D2 induces the phosphorylation of HSP in osteoblasts: function of the MAP kinase superfamily. Prostaglandins Leukotr. Essent. Fatty Acids. 2006;75:61–67

PII: S0952-3278(07)00073-7

doi: 10.1016/j.plefa.2007.06.002

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 77, Issue 1 , Pages 37-43 , July 2007

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