Higher de novo synthesized fatty acids and lower ω3- and ω6-long-chain polyunsaturated fatty acids in umbilical vessels of women with preeclampsia and high fish intakes

Huiskes, Victor J.B.; Kuipers, Remko S.; Velzing-Aarts, Francien V.; Dijck-Brouwer, D.A. Janneke; van der Meulen, Jan; Muskiet, Frits A.J.

doi:10.1016/j.plefa.2008.11.003

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Volume 80, Issue 2 , Pages 101-106, February 2009

Higher de novo synthesized fatty acids and lower ω3- and ω6-long-chain polyunsaturated fatty acids in umbilical vessels of women with preeclampsia and high fish intakes

Victor J.B. Huiskes
- Laboratory Center, University Medical Center Groningen, CMC-V, Room Y 1.147, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Remko S. Kuipers
- Laboratory Center, University Medical Center Groningen, CMC-V, Room Y 1.147, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
- Corresponding author. Tel.: +31503612733/9228; fax: +31503612290.
Francien V. Velzing-Aarts
- Laboratory Center, University Medical Center Groningen, CMC-V, Room Y 1.147, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
D.A. Janneke Dijck-Brouwer
- Laboratory Center, University Medical Center Groningen, CMC-V, Room Y 1.147, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Jan van der Meulen
- Logistics Coordinator, Haren, The Netherlands
Frits A.J. Muskiet
- Laboratory Center, University Medical Center Groningen, CMC-V, Room Y 1.147, P.O. Box 30.001, 9700 RB Groningen, The Netherlands

Received 19 May 2008; accepted 3 November 2008. published online 25 August 2009.

Abstract

Umbilical veins (UV) and arteries (UA) of preeclamptic women in Curaçao harbor lower long-chain polyunsaturated fatty acids (LCP). The present aim was to test these findings in Mwanza (Tanzania), whose inhabitants have high LCPω3 and LCPω6 intakes from Lake Victoria fish. Women with preeclampsia (n=28) in Mwanza had lower PUFA and higher 20:0 in UV and UA, compared with normotensive/non-proteinuric controls (n=31). Their UV 22:6ω3, 22:4ω6, LCPω6, ω6, and LCPω3+ω6 were lower, while saturated FA, potentially de novo synthesized FA (Σde novo) and (Σde novo)/(LCPω3+ω6) ratio were higher. Their UA had higher 16:1ω7, ω7, 18:0, and 16:1ω7/16:0. Umbilical vessels in Mwanza had higher 22:6ω3, LCPω3, ω3, and 16:0, and lower 22:5ω6, 20:2ω6, 18:1ω9, and ω9, compared to those in Curaçao. Preeclampsia in both Mwanza and Curaçao is characterized by lower LCP and higher Σde novo. An explanation of this might be placental dysfunction, while the similarity of umbilical vessel FA-abnormalities in preeclamptic and diabetic pregnancies suggests insulin resistance as a common denominator.

Keywords: Preeclampsia, Long-chain polyunsaturated fatty acids, Docosahexaenoic acid, Insulin resistance, De novo synthesized fatty acids, Fish, Mwanza, Tanzania