Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 80, Issue 2 , Pages 151-156 , February 2009

Total red blood cell concentrations of ω-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder

  • Rachel V. Gow

      Affiliations

    • Department of Child and Adolescent Psychiatry, PO Box 85, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE58AF, UK
    • Corresponding Author InformationCorresponding author. Tel.: +442078480475; fax: +442079192116.
  • ,
  • Toshiko Matsudaira

      Affiliations

    • Department of Child and Adolescent Psychiatry, PO Box 85, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE58AF, UK
  • ,
  • Eric Taylor

      Affiliations

    • Department of Child and Adolescent Psychiatry, PO Box 85, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE58AF, UK
  • ,
  • Katya Rubia

      Affiliations

    • Department of Child and Adolescent Psychiatry, Social, Genetic, Developmental Psychiatry (IRG), Social, Genetic, Developmental Psychiatry Centre (MRC), UK
  • ,
  • Michael Crawford

      Affiliations

    • Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, UK
  • ,
  • Kebreab Ghebremeskel

      Affiliations

    • Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, UK
  • ,
  • Almira Ibrahimovic

      Affiliations

    • Department of Child and Adolescent Psychiatry, PO Box 85, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE58AF, UK
  • ,
  • Frédéric Vallée-Tourangeau

      Affiliations

    • Department of Psychology, Kingston University, London, UK
  • ,
  • Leanne M. Williams

      Affiliations

    • Department of Psychological Medicine, The University of Sydney, Sydney, Australia
  • ,
  • Alexander Sumich

      Affiliations

    • Centre for Neuroimaging Sciences, King's College, London, UK

Received 17 November 2008 ,Revised 14 December 2008 ,Accepted 30 December 2008.

References 

  1. Faraone SV, Sergeant J, Gillberg C, Biederman J. The worldwide prevalence of ADHD: is it an American condition?. World Psychiatry. 2003;2:104–113
  2. Taylor E. Clinical and epidemiological foundations. In:  Taylor E editors. People with Hyperactivity: Understanding and Managing their Problems. London: MacKeith Press; 2007;p. 1–26
  3. Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol. Psychiatry. 2005;57:1336–1346
  4. Kessler RC. The national comorbidity survey replication (NCS-R): background and aims. Int. J. Methods Psychiatr. Res. 2004;13:60–68
  5. Pliszka SR. Comorbidity of attention-deficit/hyperactivity disorder with psychiatric disorders: an overview. J. Clin. Psychiatry. 1998;59:50–58
  6. Corbett B, Glidden H. Processing affective stimuli in children with attention-deficit hyperactivity disorder. Child Neuropsychol. 2000;6:144–155
  7. Faraone SV, Biederman J, Weber W, Russell RL. Psychiatric, neuropsychological, and psychosocial features of DSM-IV subtypes of attention-deficit/hyperactivity disorder: results from a clinically referred sample. J. Am. Acad. Child Adoles. Psychiatry. 1998;37:185–193
  8. Singh SD, Ellis CR, Winton AW, Singh NN, Leung JP, Oswald DP. Recognition of facial expressions of emotion by children with attention-deficit hyperactivity disorder. Behav. Modif. 1998;22:128–142
  9. Williams LM, Hermens DF, Palmer D, Kohn M, Clarke S, Keage H, et al. Misinterpreting emotional expressions in ADHD: evidence for a neural marker and stimulant effects. Biol. Psychiatry. 2008;63:917–926
  10. Marszalek JR, Lodish HF. Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu. Rev. Cell Dev. Biol. 2005;21:633–657
  11. Peet M, Horrobin DF. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with on-going depression despite apparently adequate treatment with standard drugs. Arch. Gen. Psychiatry. 2002;59:913–919
  12. Peet M. Eicosapentaenoic acid in the treatment of schizophrenia and depression: rationale and preliminary double-blind clinical trial results. Prostaglandins Leukot. Essent. Fatty Acids. 2003;69:477–485
  13. Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, Lodi L. Cognitive and physiological effects of omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur. J. Clin. Invest. 2005;35:691–699
  14. Horrobin D. The Madness of Adam and Eve: How Schizophrenia Shaped Humanity. London: Bantam Press; 2001;
  15. Sinn N, Howe PRC. Mental health benefits of omega-3 fatty acids may be mediated by improvements in cerebral vascular function. Biosci. Hypotheses. 2008;1:103–108
  16. Antalis CJ, Stevens LJ, Campbell M, Pazdro R, Ericson K, Burgess J. Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins Leukot. Essent. Fatty Acids. 2006;75:299–308
  17. Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, et al. Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J. Clin. Psychiatry. 2006;67:1954–1967
  18. Conklin SM, Manuck SP, Yao J, Flory JD, Hibbeln JR, Muldoon M. High ω-6 and low ω-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom. Med. 2007;69:932–934
  19. McNamara RK, Carlson SE. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot. Essent. Fatty Acids. 2006;75:329–349
  20. Reisbick S, Neuringer M, Hasnain R, Connor WE. Home cage behavior of rhesus monkeys with long-term deficiency of omega-3 fatty acids. Physiol. Behav. 1994;55:231–239
  21. McLoughlin G, Kuntsi J, Brandeis D, Banaschewski T. Electrophysiological parameters in psychiatric research: ADHD. J. Neurophysiol. 2005;4:14–18
  22. Banaschewski T, Brandeis D. Annotation: what electrical brain activity tells us about brain function that other techniques cannot tell us—a child psychiatric perspective. J. Child Psychol. Psychiatry. 2006;48:415–435
  23. Balconi M, Lucchiari C. In the face of emotions: event related potentials in supraliminal and subliminal facial expression recognition. Genet. Soc. Gen. Psychol. Monogr. 2005;131:41–69
  24. Cavanagh J, Geisler MW. Mood effects on the ERP processing of emotional intensity in faces: a P3 investigation with depressed students. Int. J. Psychophysiol. 2006;60:27–33
  25. Luck SJ. An Introduction to the Event Related Potential Technique. London: MIT Press; 2005;
  26. Mogg K, Bradley BP. A cognitive-motivational analysis of anxiety. Behav. Res. Ther. 1998;36:809–848
  27. Deeley Q, Daly E, Surguladze S, Tunstall N, Mezey G, Beer D, et al. Facial emotion processing in criminal psychopathy. Br. J. Psychiatry. 2006;189:533–539
  28. Pelc K, Kornreich C, Foisy ML, Dan B. Recognition of emotional facial expressions in attention deficit hyperactivity disorder. Pediatr. Neurol. 2006;35:93–97
  29. Hruby T, Marsalek P. Event-related potentials—the P300 wave. Acta Neurobiol. Exp. 2003;63:55–63
  30. Polich J, Herbst KL. P300 as a clinical assay: rationale, evaluation, and findings. Int. J. Psychophysiol. 2000;38:3–19
  31. Williams LM, Liddell BJ, Kemp AH, Bryant RA, Meares RA, Peduto AS, et al. Amygdala-prefrontal dissociation of subliminal and supraliminal fear. Hum. Brain Mapp. 2006;27:652–661
  32. Williams LM, Palmer D, Liddell BJ, Song Le, Gordon E. The ‘when’ and ‘where’ of perceiving signals of threat versus non-threat. NeuroImage. 2006;31:458–467
  33. Conners CK, Sitarenios G, Parker JDA, Epstein JN. Revision and restandardization of the conners teacher rating scale (CTRS-R): factor structure, reliability, and criterion validity. J. Abnorm. Child Psychol. 1998;26:279–291
  34. Kaufman AS, Kaufman NL. Kaufman Adolescent and Adult Intelligence Test. Circle Pines, MN: American Guidance Service; 1993;
  35. Rooney MT, Fristad MA, Weller EB, Weller RA. Administration Manual for the ChIPS. Washington, DC: American Psychiatric Publishing; 1999;
  36. Gordon E, Cooper N, Rennie C, Hermens D, Williams LM. Integrative neuroscience: the role of a standardised database. Clin. EEG Neurosci. 2005;36:64–75
  37. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissue. J. Biol. Chem. 1957;226:497–509
  38. Gur RC, Sara R, Hagendoorn M, Marom O, Hughett P, Macy L, et al. A method for obtaining 3-dimmensional facial expressions and its standardisation for use in neurocognitive studies. J. Neurosci. Methods. 2002;115:137–143
  39. Fallgatter AJ, Ehlis AC, Seifert J, Strik WK, Scheuerpflug P, Zillessen KE, et al. Altered response control and anterior cingulated function in attention-deficit/hyperactivity disorder boys. Clin. Neurophysiol. 2004;115:973–981
  40. Liddell BJ, Williams LM, Rathjen J, Shevrin H, Gordon E. A temporal dissociation of subliminal versus supraliminal fear perception: an event-related potential study. J. Cogn. Neurosci. 2004;16:479–486
  41. Whalley LJ, Fox HC, Wahle KW, Starr JM, Deary IJ. Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids,. Am. J. Clin. Nutr. 2004;80:1650–1657
  42. Perry RJ, Rosen HR, Kramer JH, Beer JS, Levenson RL, Miller BL. Hemispheric dominance for emotions, empathy and social behaviour: evidence from right and left handers with frontotemporal dementia. Neurocase. 2001;7:145–160
  43. Frick PJ, Stickle TR, Dandreaux DM, Farrell JM, Kimonis ER. Callous-unemotional traits in predicting the severity and stability of conduct problems and delinquency. Curr. Psychiatry Rep. 2005;33:471–487
  44. Blair RJR. Neurobiological basis of psychopathy. Br. J. Psychiatry. 2003;182:5–7
  45. Gesch B, Hammond SM, Hampson SE, Eves A, Crowder MJ. Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Br. J. Psychiatry. 2002;181:22–28
  46. Fusar-Poli P, Allen P, Lee F, Surguladze S, Tunstall N, Fu CHY, et al. Modulation of neural response to happy and sad faces by acute tryptophan depletion. J. Psychopharmacol. 2007;193:31–44
  47. Takeuchi T, Fukumoto Y, Harada E. Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. Behav. Brain Res. 2002;131:193–203
  48. Mathieu G, Denis S, Lavialle M, Vancassel S. Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats. Prostaglandins Leukot. Essent. Fatty Acids. 2008;78:391–401
  49. Julien RM. A Primer of Drug Action. New York: Worth; 2004;

PII: S0952-3278(09)00002-7

doi: 10.1016/j.plefa.2008.12.007

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 80, Issue 2 , Pages 151-156 , February 2009