Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 80, Issue 2 , Pages 93-99 , February 2009

Fatty acid uptake by breast cancer cells (MDA-MB-231): Effects of insulin, leptin, adiponectin, and TNFα

Received 30 May 2008 ,Revised 28 December 2008 ,Accepted 7 January 2009.

References 

  1. Byrne C, Rockett H, Holmes MD. Dietary fat, fat subtypes, and breast cancer risk: lack of an association among postmenopausal women with no history of benign breast disease. Cancer Epidemiol. Biomarkers Prev. 2002;11:261–265
  2. Velie E, Kulldorff M, Schairer C, Block G, Albanes D, Schatzkin A. Dietary fat, fat subtypes, and breast cancer in postmenopausal women: a prospective cohort study. J. Natl. Cancer Inst. 2000;92:833–839
  3. Bagga D, Anders KH, Wang HJ, Glaspy JA. Long-chain n-3-to-n-6 polyunsaturated fatty acid ratios in breast adipose tissue from women with and without breast cancer. Nutr. Cancer. 2002;42:180–185
  4. Maillard V, Bougnoux P, Ferrari P, Jourdan ML, Pinault M, Lavillonniere F, et al. N-3 and N-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France. Int. J. Cancer. 2002;98:78–83
  5. Klein V, Chajes V, Germain E, Schulgen G, Pinault M, Malvy D, et al. Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. Eur. J. Cancer. 2000;36:335–340
  6. Schley PD, Jijon HB, Robinson LE, Field CJ. Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast Cancer Res. Treat. 2005;92:187–195
  7. Mukutmoni-Norris M, Hubbard NE, Erickson KL. Modulation of murine mammary tumor vasculature by dietary n-3 fatty acids in fish oil. Cancer Lett. 2000;150:101–109
  8. Wu M, Harvey KA, Ruzmetov N, Welch ZR, Sech L, Jackson K, et al. Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway. Int. J. Cancer. 2005;117:340–348
  9. Sauer LA, Dauchy RT, Blask DE, Krause JA, Davidson LK, Dauchy EM. Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. J. Nutr. 2005;135:2124–2129
  10. Goodstine SL, Zheng T, Holford TR, Ward BA, Carter D, Owens PH, et al. Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in US women. J. Nutr. 2003;133:1409–1414
  11. Simonsen NR, Fernandez-Crehuet NJ, Martin-Moreno JM, Strain JJ, Huttunen JK, Martin BC, et al. Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. European community multicenter study on antioxidants, myocardial infarction, and breast cancer. Am. J. Clin. Nutr. 1998;68:134–141
  12. Terry P, Rohan TE, Wolk A, Maehle-Schmidt M, Magnusson C. Fish consumption and breast cancer risk. Nutr. Cancer. 2002;44:1–6
  13. Folsom AR, Demissie Z. Fish intake, marine omega-3 fatty acids, and mortality in a cohort of postmenopausal women. Am. J. Epidemiol. 2004;160:1005–1010
  14. Engeset D, Alsaker E, Lund E, Welch A, Khaw KT, Clavel-Chapelon F, et al. Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC). Int. J. Cancer. 2006;119:175–182
  15. Chajes V, Bougnoux P. Omega-6/omega-3 polyunsaturated fatty acid ratio and cancer. World Rev. Nutr. Diet. 2003;92:133–151
  16. Chajes V, Lavillonniere F, Maillard V, Giraudeau B, Jourdan ML, Sebedio JL, et al. Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. Nutr. Cancer. 2003;45:17–23
  17. Honn KV, Tang DG, Gao X, Butovich IA, Liu B, Timar J, et al. 12-lipoxygenases and 12(S)-HETE: role in cancer metastasis. Cancer Metastasis Rev. 1994;13:365–396
  18. Tang DG, Renaud C, Stojakovic S, Diglio CA, Porter A, Honn KV. 12(S)-HETE is a mitogenic factor for microvascular endothelial cells: its potential role in angiogenesis. Biochem. Biophys. Res. Commun. 1995;211:462–468
  19. Duttaroy AK. Insulin mediated processes in platelets, erythrocytes and monocytes/macrophages: effects of essential fatty acid metabolism. Prostaglandins Leukot. Essent. Fatty Acids. 1994;51:385–399
  20. Rose DP, Komninou D, Stephenson GD. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes. Rev. 2004;5:153–165
  21. Wolf I, Sadetzki S, Catane R, Karasik A, Kaufman B. Diabetes mellitus and breast cancer. Lancet Oncol. 2005;6:103–111
  22. Stephenson GD, Rose DP. Breast cancer and obesity: an update. Nutr. Cancer. 2003;45:1–16
  23. Del Giudice ME, Fantus IG, Ezzat S, Keown-Eyssen G, Page D, Goodwin PJ. Insulin and related factors in premenopausal breast cancer risk. Breast Cancer Res. Treat. 1998;47:111–120
  24. Papa V, Belfiore A. Insulin receptors in breast cancer: biological and clinical role. J. Endocrinol. Invest. 1996;19:324–333
  25. Miyaoka K, Kuwasako T, Hirano K, Nozaki S, Yamashita S, Matsuzawa Y. CD36 deficiency associated with insulin resistance. Lancet. 2001;357:686–687
  26. Yanai H, Chiba H, Fujiwara H, Morimoto M, Takahashi Y, Hui SP, et al. Metabolic changes in human CD36 deficiency displayed by glucose loading. Thromb. Haemost. 2001;86:995–999
  27. Hajri T, Han XX, Bonen A, Abumrad NA. Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J. Clin. Invest. 2002;109:1381–1389
  28. Schaffler A, Scholmerich J, Buechler C. Mechanisms of disease: adipokines and breast cancer-endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat. Clin. Pract. Endocrinol. Metab. 2007;3:345–354
  29. Fraser SP, Diss JK, Chioni AM, Mycielska ME, Pan H, Yamaci RF, et al. Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin. Cancer Res. 2005;11:5381–5389
  30. Campbell FM, Clohessy AM, Gordon MJ, Page KR, Duttaroy AK. Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid binding protein. Journal of Lipid Research. 1997;38:2558–2568
  31. Crabtree JT, Gordon MJ, Campbell FM, Duttaroy AK. Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. Molecular and Cellular Biochemistry. 1998;185:191–198
  32. Potashnik R, Bloch-Damti A, Bashan N, Rudich A. IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress. Diabetologia. 2003;46:639–648
  33. Schmitz G, Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog. Lipid Res. 2008;47:147–155
  34. Horia E, Watkins BA. Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures. J. Nutr. Biochem. 2005;16:184–192
  35. Duttaroy AK. Cellular uptake of long-chain fatty acids: role of membrane-associated fatty-acid-binding/transport proteins. Cellular and Molecular Life Sciences. 2000;57:1360–1372
  36. Finstad HS, Dyrendal H, Myhrstad MC, Heimli H, Drevon CA. Uptake and activation of eicosapentaenoic acid are related to accumulation of triacylglycerol in Ramos cells dying from apoptosis. J. Lipid Res. 2000;41:554–563
  37. Schurer NY, Stremmel W, Grundmann JU, Schliep V, Kleinert H, Bass NM, et al. Evidence for a novel keratinocyte fatty acid uptake mechanism with preference for linoleic acid: comparison of oleic and linoleic acid uptake by cultured human keratinocytes, fibroblasts and a human hepatoma cell line. Biochim. Biophys. Acta. 1994;1211:51–60
  38. Uriel J, Torres JM, Anel A. Carrier-protein-mediated enhancement of fatty-acid binding and internalization in human T-lymphocytes. Biochim. Biophys. Acta. 1994;1220:231–240
  39. Stoll BA. Upper abdominal obesity, insulin resistance and breast cancer risk. Int. J. Obes. Relat Metab Disord. 2002;26:747–753
  40. Muti P, Quattrin T, Grant BJB, Krogh V, Micheli A, Schunemann HJ, et al. Fasting glucose is a risk factor For breast cancer: a prospective study. Cancer Epidemiol Biomarkers Prev. 2002;11:1361–1368
  41. Straus DS. Growth-stimulatory actions of insulin in vitro and in vivo. Endocr. Rev. 1984;5:356–369
  42. Lippman ME, Osborne CK, Knazek R, Young N. In vitro model systems for the study of hormone-dependent human breast cancer. N. Engl. J. Med. 1977;296:154–159
  43. Osborne CK, Bolan G, Monaco ME, Lippman ME. Hormone responsive human breast cancer in long-term tissue culture: effect of insulin. Proc. Natl. Acad. Sci. USA. 1976;73:4536–4540
  44. Papa V, Belfiore A. Insulin receptors in breast cancer: biological and clinical role. J. Endocrinol. Invest. 1996;19:324–333
  45. Costantino A, Milazzo G, Giorgino F, Russo P, Goldfine ID, Vigneri R, et al. Insulin-resistant MDA-MB231 human breast cancer cells contain a tyrosine kinase inhibiting activity. Mol. Endocrinol. 1993;7:1667–1676
  46. Barb D, Williams CJ, Neuwirth AK, Mantzoros CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am. J. Clin. Nutr. 2007;86:s858–s866
  47. Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, et al. Adiponectin and breast cancer risk. J. Clin. Endocrinol. Metab. 2004;89:1102–1107
  48. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, Matsuzawa Y, et al. Association of serum adiponectin levels with breast cancer risk. Clin. Cancer Res. 2003;9:5699–5704
  49. Wolf I, Sadetzki S, Kanety H, Kundel Y, Pariente C, Epstein N, et al. Adiponectin, ghrelin, leptin in cancer cachexia in breast, colon cancer patients. Cancer. 2006;106:966–973
  50. Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, et al. Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res. 2006;66:11462–11470
  51. Dieudonne MN, Bussiere M, Dos Santos E, Leneveu MC, Giudicelli Y, Pecquery R. Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem. Biophys. Res. Commun. 2006;345:271–279
  52. Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, et al. Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res. 2006;66:11462–11470
  53. Stattin P, Soderberg S, Biessy C, Lenner P, Hallmans G, Kaaks R, et al. Plasma leptin and breast cancer risk: a prospective study in northern Sweden. Breast Cancer Res. Treat. 2004;86:191–196
  54. Wang L, Lim EJ, Toborek M, Hennig B. The role of fatty acids and caveolin-1 in tumor necrosis factor a-induced endothelial cell activation. Metabolism Clin. Exptl. 2008;57:1328–1339
  55. Pohl J, Ring A, Ehehalt R, Herrmann T, Stremmel W. New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae. Proc. Nutr. Soc. 2004;63:259–262

PII: S0952-3278(09)00005-2

doi: 10.1016/j.plefa.2009.01.002

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 80, Issue 2 , Pages 93-99 , February 2009