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Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 81, Issue 4
, Pages 253-264
, October 2009
Novel plasma phospholipid biomarkers of autism: Mitochondrial dysfunction as a putative causative mechanism
References
- American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, fourth ed., 1994.
- . Prevalence of autism in a US metropolitan area. Jama. 2003;289(1):49–55
- . The developmental neurobiology of autism spectrum disorder. J. Neurosci. 2006;26(26):6897–6906
- . Epidemiological surveys of autism and other pervasive developmental disorders: an update. J. Autism. Dev. Disord. 2003;33(4):365–382
- . Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 2005;57(1):67–81
- . Neuropathological findings in autism. Brain. 2004;127(Part 12):2572–2583
- . Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Curr. Opin. Neurobiol. 1997;7(2):269–278
- . The autistic brain: birth through adulthood. Curr. Opin. Neurol. 2004;17(4):489–496
- . Localization of white matter volume increase in autism and developmental language disorder. Ann. Neurol. 2004;55(4):530–540
- . Investigation of antioxidant enzymes in children with autistic disorder. Prostaglandins Leukot. Essent. Fatty Acids. 2002;67(5):341–343
- . Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin – the antioxidant proteins. Life Sci. 2004;75(21):2539–2549
- . Oxidative stress in autism. Pathophysiology. 2006;13(3):171–181
- . Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am. J. Clin. Nutr. 2004;80(6):1611–1617
- . Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. Clin. Chim. Acta. 2003;331(1–2):111–117
- . Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism. Eur. Arch. Psychiatry Clin. Neurosci. 2004;254(3):143–147
- . Abnormal melatonin synthesis in autism spectrum disorders. Mol. Psychiatry. 2008;13(1):90–98
- . Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism?. Neuro. Endocrinol. Lett. 2006;27(4):465–471
- . Evidence of toxicity, oxidative stress, and neuronal insult in autism. J. Toxicol. Environ. Health B Crit. Rev. 2006;9(6):485–499
- . Neuroanatomic observations of the brain in autism: a review and future directions. Int. J. Dev. Neurosci. 2005;23(2–3):183–187
- . Nontargeted metabolome analysis by use of fourier transform Ion cyclotron mass spectrometry. Omics. 2002;6(3):217–234
- . Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. J. Lipid Res. 2007;48(11):2485–2498
- . Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC–MS quantitation of tBDMS derivatives using ammonia positive chemical ionization. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2006;831:313–319
- . A clinical and laboratory evaluation of methionine cycle-transsulfuration and androgen pathway markers in children with autistic disorders. Horm. Res. 2006;66(4):182–188
- . Relative carnitine deficiency in autism. J. Autism. Dev. Disord. 2004;34(6):615–623
- . Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death. Neuroscience. 2000;97(3):531–541
- . Suppression of the mitochondrial oxidation of (-)-palmitylcarnitine by the malate-aspartate and alpha-glycerophosphate shuttles. J. Biol. Chem. 1976;251(2):277–284
- . Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices. Toxicol. In Vitro. 2006;20(7):1173–1182
- . Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes. Biochem. J. 1992;281(Part 2):561–567
- . 1-Alkenyl group of ethanolamine plasmalogen derives mainly from de novo-synthesized fatty alcohol within peroxisomes, but not extraperoxisomal fatty alcohol or fatty acid. J. Biochem. (Tokyo). 1997;121(5):978–983
- . Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver. J. Lipid Res. 1993;34(3):467–477
- . The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase. J. Biol. Chem. 1991;266(30):19995–20000
- . The genetics of autism. Pediatrics. 2004;113(5):e472–e486
- . System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes. J. Immunol. 2007;178(10):6549–6556
- . Excitotoxic damage to white matter. J. Anat. 2007;210(6):693–702
- . Factors controlling the rate of fatty acid-oxidation in rat liver mitochondria. Biochim. Biophys. Acta. 1972;280(4):515–530
- . Mitochondrial beta-oxidation. Eur. J. Biochem. 2004;271(3):462–469
- . Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J. Biol. Chem. 1998;273(10):5678–5684
- . Flux of palmitate through the peroxisomal and mitochondrial beta-oxidation systems in isolated rat hepatocytes. Biochim. Biophys. Acta. 1985;835(1):147–153
- . Role of peroxisomal fatty acyl-CoA beta-oxidation in phospholipid biosynthesis. Arch. Biochem. Biophys. 1991;284(2):326–331
- . Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart. J. Biol. Chem. 2004;279(19):19574–19579
- . Incorporation of acetyl-CoA generated from peroxisomal beta-oxidation into ethanolamine plasmalogen of rat liver. Biochim. Biophys. Acta. 1995;1254(3):319–325
- . Fatty alcohol synthesis accompanied with chain elongation in liver peroxisomes. Biochim. Biophys. Acta. 1997;1346(1):38–44
- . Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J. Lipid Res. 1995;36(12):2471–2477
- . Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. J. Lipid Res. 1999;40(3):495–503
- . Very long-chain fatty acids in diagnosis, pathogenesis, and therapy of peroxisomal disorders. Lipids. 1996;31(Suppl.):S141–S144
- . Elongation of very long-chain fatty acids is enhanced in X-linked adrenoleukodystrophy. Mol. Genet. Metab. 2005;84(2):144–151
- . Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha). Biochemistry. 2006;45(24):7669–7681
- . Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J. Lipid Res. 2006;47(9):2028–2041
- . Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. J. Lipid Res. 2005;46(4):706–715
- . Acetyl-l-carnitine physical–chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Mol. Psychiatry. 2000;5(6):616–632
- . Carnitine – a known compound, a novel function in neural cells.. Acta Neurobiol. Exp. (Wars). 1996;56(2):597–609
- . The role of carnitine in intracellular metabolism. J. Clin. Chem. Clin. Biochem. 1990;28(5):297–301
- . Carnitine. Annu. Rev. Biochem. 1988;57:261–283
- . Delta-6 desaturation of alpha-linolenic acid in brain and liver during development and aging in the mouse. Neurosci. Lett. 1992;141(1):65–68
- . Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc. Natl. Acad. Sci. USA. 1989;86(8):2903–2907
- . Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Dev. Med. Child Neurol. 2005;47(3):185–189
- . Lack of adrenoleukodystrophy protein enhances oligodendrocyte disturbance and microglia activation in mice with combined Abcd1/Mag deficiency. Acta Neuropathol. 2007;114(6):573–586
- . Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy. J. Lipid Res. 2008;
- . Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage. Hum. Mol. Genet. 2005;14(23):3565–3577
- . Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity. Brain Res. 2008;1210:11–19
- . Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons. J. Immunol. 1994;152(7):3578–3585
- . Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism. J. Neuropathol. Exp. Neurol. 2004;63(9):964–977
- . Neurons depend on astrocytes in a coculture system for protection from glutamate toxicity. Mol. Cell Neurosci. 1999;13(5):379–389
- . Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci. Lett. 1989;103(2):162–168
- . Epidemiology of autistic disorder and other pervasive developmental disorders. J. Clin. Psychiatry. 2005;66(Suppl. 10):3–8
- . The epidemiology of autism: a review. Psychol. Med. 1999;29(4):769–786
- . The UCLA-University of Utah epidemiologic survey of autism: prevalence. Am. J. Psychiatry. 1989;146(2):194–199
- . Effect of puberty on the relationship between circulating leptin and body composition. J. Clin. Endocrinol. Metab. 2000;85(7):2509–2518
- . Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J. Clin. Invest. 1994;94(6):2475–2480
- . Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons. J. Neurochem. 1996;66(5):1836–1844
- . Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration. J. Neurosci. 2001;21(8):2600–2609
- . Neuroprotective effects of estradiol in newborn female rat hippocampus. Brain Res. Dev. Brain Res. 2004;150(2):191–198
- . 17alpha-Estradiol is neuroprotective in male and female rats in a model of early brain injury. Exp. Neurol. 2008;210(1):41–50
- . 17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway. Brain Res. 2001;901(1–2):230–236
- . Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proc. Natl. Acad. Sci. USA. 2003;100(5):2842–2847
- . Estrogen protects primary cortical neurons from glutamate toxicity. Neurosci. Lett. 1996;212(1):13–16
- . Effects of caudal hindbrain lactate infusion on insulin-induced hypoglycemia and neuronal substrate transporter glucokinase and sulfonylurea receptor-1 gene expression in the ovariectomized female rat dorsal vagal complex: impact of estradiol. J. Neurosci. Res. 2008;86(3):694–701
- . Equine estrogens differentially inhibit DNA fragmentation induced by glutamate in neuronal cells by modulation of regulatory proteins involved in programmed cell death. BMC Neurosci. 2003;4:32
- . A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice. J. Clin. Invest. 1998;102(6):1083–1091
- . Mechanisms of glial swelling induced by glutamate. Can. J. Physiol. Pharmacol. 1992;70(Suppl.):S334–S343
- . Prospective study of transsulfuration biomarkers in autistic disorders. Neurochem. Res. 2008;
- . Gliotoxic action of glutamate on cultured astrocytes. J. Neurochem. 2000;75(4):1557–1565
- . Increased excretion of a lipid peroxidation biomarker in autism. Prostaglandins Leukot. Essent. Fatty Acids. 2005;379(5):379–384
- . Neurotoxicity of reactive aldehydes: the concept of “aldehyde load” as demonstrated by neuroprotection with hydroxylamines. Brain Res. 2006;1095(1):190–199
- . Oxidative and antioxidative potential of brain microglial cells. Antioxidants Redox Signaling***. 2005;7(9–10):1223–1233
- . Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?. Ann. Neurol. 2008;63(6):729–742
- . Plasmalogens participate in very-long-chain fatty acid-induced pathology.. Brain. 2009;132:482–492
- . A possible central mechanism in autism spectrum disorders, Part I. Altern. Ther. Health Med. 2008;14(6):46–53
PII: S0952-3278(09)00111-2
doi: 10.1016/j.plefa.2009.06.003
© 2009 Elsevier Ltd. All rights reserved.
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Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 81, Issue 4
, Pages 253-264
, October 2009
