Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 81, Issue 5 , Pages 303-305 , November 2009

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome)

  • B.K. Puri

      Affiliations

    • MRI Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, England, UK
    • Corresponding Author InformationCorresponding author. Tel: +442083832412; fax: +442083833038.
    • ,
  • M. Agour

      Affiliations

    • Department of Psychiatry, Cambridge, and University of Hertfordshire, UK
    • ,
  • K.D.R. Gunatilake

      Affiliations

    • Brooklands Hospital, Coleshill Road, Marston Green, Birmingham B37 7HL, UK
    • ,
  • K.A.C. Fernando

      Affiliations

    • The Greenfields, Monyhull Hall Road, Kings Norton, Birmingham B30 3QQ, UK
    • ,
  • A.I. Gurusinghe

      Affiliations

    • Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex UB8 3NN, UK
    • ,
  • I.H. Treasaden

      Affiliations

    • Three Bridges Medium Secure Unit, West London Mental Health NHS Trust, Uxbridge Road, Middlesex UB1 3EU and Head of Forensic Neurosciences, Lipid Neuroscience Group, Imperial College London, England, UK

References 

  1. Richards RS, Roberts TK, McGregor NR, Dunstan RH, Butt HL. Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome. Redox Rep. 2000;5:35–41
  2. Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radical Biol. Med. 2005;39:584–589
  3. Halliwell B, Gutteridge JMC. Free radicals in Biology and Medicine. Oxford, New York: Oxford University Press; 2007;
  4. Aoki T, Miyakoshi H, Usuda Y, Herberman RB. Low NK syndrome and its relationship to chronic fatigue syndrome. Clin. Immunol. Immunopathol. 1993;69:253–265
  5. Droge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J. 1997;11:1077–1089
  6. Manuel B, Keenoy Y, Moorkens G, Vertommen J, Noe M, Neve J, et al. Magnesium status and parameters of the oxidant–antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J. Am. Coll. Nutr. 2000;19:374–382
  7. Kurup RK, Kurup PA. Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis. Int. J. Neurosci. 2003;113:683–701
  8. Wood SJ, Berger GE, Wellard RM, Proffitt TM, McConchie M, Berk M, et al. Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation. Neurobiol. Dis. 2009;33:354–357
  9. Vanhamme L, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J. Magn. Reson. 1997;129:35–43
  10. Naressi A, Couturier C, Devos JM, Janssen M, Mangeat C, de Beer R, et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA. 2001;12:141–152

PII: S0952-3278(09)00172-0

doi: 10.1016/j.plefa.2009.10.002

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 81, Issue 5 , Pages 303-305 , November 2009

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