Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 2 , Pages 83-86, February 2010

A cautionary note on the correct structure assignment of phytoprostanes and the emergence of a new prostane ring system

  • Ullrich Jahn

      Affiliations

    • Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague, Czech Republic
    • Corresponding Author InformationCorresponding authors.
    • ,
  • Jean-Marie Galano

      Affiliations

    • Institut des Biomolécules Max Mousseron, IBMM, UMR CNRS 5247, Université Montpellier I, Université Montpellier II, Faculté de Pharmacie, 15. Av. Ch. Flahault, F-34093 Montpellier cedex 05, France
    • Corresponding Author InformationCorresponding authors.
    • ,
  • Thierry Durand

      Affiliations

    • Institut des Biomolécules Max Mousseron, IBMM, UMR CNRS 5247, Université Montpellier I, Université Montpellier II, Faculté de Pharmacie, 15. Av. Ch. Flahault, F-34093 Montpellier cedex 05, France
    • Corresponding Author InformationCorresponding authors.

Received 29 July 2009; received in revised form 8 October 2009; accepted 11 October 2009. published online 25 January 2010.

Abstract 

Considerable confusion exists about the correct structural representation of phytoprostanes (PhytoP). Improper use of the different nomenclature systems leads to incorrect structure assignment of PhytoP, which results in wrong synthetic approaches to these molecules and may lead to wrong rationalization of biological activity. A new prostane ring system was found, which is proposed to be termed L1-PhytoP or L2-IsoP, respectively.

Keywords: Phytoprostanes, Isoprostanes, Structure, Biological activity

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PII: S0952-3278(09)00175-6

doi:10.1016/j.plefa.2009.10.005

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 2 , Pages 83-86, February 2010

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