Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 2 , Pages 121-129 , February 2010

Cloning, purification and characterization of non-human primate 12/15-lipoxygenases

  • M. Johannesson

      Affiliations

    • Orexo AB, P.O. Box 303, 751 05 Uppsala, Stockholm, Sweden
  • ,
  • L. Backman

      Affiliations

    • Orexo AB, P.O. Box 303, 751 05 Uppsala, Stockholm, Sweden
  • ,
  • H.-E. Claesson

      Affiliations

    • Orexo AB, P.O. Box 303, 751 05 Uppsala, Stockholm, Sweden
    • Department of Medical Biophysics and Biochemistry, Karolinska Institutet, Stockholm, Sweden
  • ,
  • P.K.A. Forsell

      Affiliations

    • Orexo AB, P.O. Box 303, 751 05 Uppsala, Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46187808954; fax.: +46187808999.

Received 19 August 2009 ,Revised 7 October 2009 ,Accepted 29 November 2009.

References 

  1. Radmark O. Arachidonate 5-lipoxygenase. Prostaglandins Other Lipid Mediators. 2002;68–69:211–234
  2. Yoshimoto T, Takahashi Y. Arachidonate 12-lipoxygenases. Prostaglandins Other Lipid Mediators. 2002;68–69:245–262
  3. Kuhn H, Walther M, Kuban R. Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications. Prostaglandins Other Lipid Mediators. 2002;68–69:263–290
  4. Brash AR. Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J. Biol. Chem. 1999;274:23679–23682
  5. Oliw E. Plant and fungal lipoxygenases. Prostaglandins Other Lipid Mediators. 2002;68–69:313–323
  6. Andreou A, Brodhun F, Feussner I. Biosynthesis of oxylipins in non-mammals. Prog. Lipid Res. 2009;48:148–170
  7. Rapoport S, Schewe T, Wiesner R, Halangk W, Ludwig P, Janicke-Hohne M, et al. The lipoxygenase of reticulocytes. Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte. Eur. J. Biochem. 1979;96:545–561
  8. Jayawickreme SP, Gray T, Nettesheim P, Eling T. Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 1999;276:L596–L603
  9. Turk J, Maas R, Brash A, Roberts L, Oates J. Arachidonic acid 15-lipoxygenase products from human eosinophils. J. Biol. Chem. 1982;257:7068–7076
  10. Conrad D, Kuhn H, Mulkins M, Highland E, Sigal E. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. PNAS. 1992;89:217–221
  11. Spanbroek R, Hildner M, Kohler A, Muller A, Zintl F, Kuhn H, et al. IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression. PNAS. 2001;98:5152–5157
  12. Gulliksson M, Brunnstrom A, Johannesson M, Backman L, Nilsson G, Harvima I, et al. Expression of. 15-lipoxygenase type-1 in human mast cells. Biochim. Biophys. Acta. 2007;1771:1156–1165
  13. H-E. Claesson, W. Griffiths, A. Brunnstrom, F. Schain, E. Andersson, S. Feltenmark, H. Johnson, A. Porwit, J. Sjoberg, M. Bjorkholm, Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. FEBS J 275 (2008) 4222-4234.
  14. Feltenmark S, Gautam N, Brunnstrom A, Griffiths W, Backman L, Edenius C, et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. PNAS. 2008;105:680–685
  15. Chu H, Balzar S, Westcott J, Trudeau J, Sun Y, Conrad D, et al. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin. Exp. Allergy. 2002;32:1558–1565
  16. Bradding P, Redington A, Djukanovic R, Conrad D, Holgate S. 15-lipoxygenase immunoreactivity in normal and in asthmatic airways. Am. J. Respir. Crit. Care Med. 1995;151:1201–1204
  17. Hajek AR, Lindley AR, Favoreto S, Carter R, Schleimer RP, Kuperman DA. 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. J. Allergy Clin. Immunol. 2008;122:633–639
  18. Andersson CK, Claesson H-E, Rydell-Tormanen K, Swedmark S, Hallgren A, Erjefalt JS. Mice lacking 12/15-lipoxygenase have attenuated airway allergic inflammation and remodeling. Am. J. Respir. Cell Mol. Biol. 2008;39:648–656
  19. Planaguma A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, et al. Airway Lipoxin A4 generation and Lipoxin A4 receptor expression are decreased in severe asthma. Am. J. Respir. Crit. Care Med. 2008;178:574–582
  20. Thiele B, Berger M, Schwarz K, Borngraber S, Kuhn H, Ostareck-Lederer A, et al. Expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits. Adv. Exp. Med. Biol. 1999;447:45–61
  21. Berger M, Schwarz K, Thiele H, Reimann I, Huth A, Borngraber S, et al. Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits. J. Mol. Biol. 1998;278:935–948
  22. Gillmor S, Villasenor A, Fletterick R, Sigal E, Browner M. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat. Struct. Biol. 1997;4:1003–1009
  23. Gan Q-F, Browner MF, Sloane DL, Sigal E. Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis. J. Biol. Chem. 1996;271:25412–25418
  24. Borngraber S, Kuban R, Anton M, Kuhn H. Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases. J. Mol. Biol. 1996;264:1145–1153
  25. Borngraber S, Kuban R, Kuhn H. Sequence determinants for the positional specificity of mammalian and plant lipoxygenases. Adv. Exp. Med. Biol. 1999;469:91–97
  26. Liminga M, Fagerholm P, Oliw E. Lipoxygenases in corneal epithelia of man and cynomolgus monkey. Exp. Eye Res. 1994;59:313–321
  27. Kulkarni P, Kaufman P, Srinivasan B. Cyclo-oxygenase and lipoxygenase pathways in cynomolgus and rhesus monkey conjunctiva, anterior uvea and eyelids. Curr. Eye Res. 1987;6:801–808
  28. Smith GCS, Wu WX, Nathanielsz PW. Lipoxygenase gene expression in baboon intrauterine tissues in late pregnancy and parturition. Mol. Hum. Reprod. 2001;7:587–594
  29. Turner C, Smith W, Andresen C, Eggler J, Watson J. The effect of 5-lipoxygenase inhibition on Ascaris antigen (Ag)-induced responses in atopic monkeys. Inflamm. Res. 1996;45:42–49
  30. Weichman B, Muccitelli R, Tucker S, DeVan J. Effect of calcium antagonists on the biosynthesis and contractile effects of peptidoleukotrienes in rhesus monkey lung. J. Pharmacol. Exp. Ther. 1985;233:345–351
  31. Kawajiri H, Hsi L, Kamitani H, Ikawa H, Geller M, Ward T, et al. Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. Arch. Biochem. Biophys. 2002;398:51–60
  32. Kumar S, Tamura T, Nei M. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Briefings in Bioinformatics. 2004;5:150–163
  33. Kanicky J, Shah D. Effect of degree, type, and position of unsaturation on the pKa of long-chain fatty acids. J. Colloid Interface Sci. 2002;256:201–207
  34. Kanicky J, Poniatowski AF, Mehta NR, Shah DO. Cooperativity among molecules at interfaces in relation to various technological processes. Effect of chain length on the pKa of fatty acid salt solutions. Langmuir. 1999;16:172–177
  35. Brash AR, Boeglin WE, Chang MS. Discovery of a second 15S-lipoxygenase in humans. PNAS. 1997;94:6148–6152
  36. Gonzalez A, Roberts R, Massion P, Olson S, Shyr Y, Shappell S. 15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation. Hum. Pathol. 2004;35:840–849

 Grant support: This work was financially supported by Orexo AB, Karolinska Institutet and by the European Commission FP6 Grant LSHM-CT-2004-005033.

PII: S0952-3278(09)00202-6

doi: 10.1016/j.plefa.2009.11.006

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 2 , Pages 121-129 , February 2010