Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 277-280 , April 2010

Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: Higher fish intake or aging-related change in n-3 fatty acid metabolism?

  • M. Fortier

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • ,
  • J. Tremblay-Mercier

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • ,
  • M. Plourde

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • ,
  • R. Chouinard-Watkins

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • ,
  • M. Vandal

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • ,
  • F. Pifferi

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • ,
  • E. Freemantle

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • ,
  • S.C. Cunnane

      Affiliations

    • Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Quebec, Canada J1H 4C4
    • Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada J1H 4C4
    • Corresponding Author InformationCorresponding author at: Research Center on Aging, 1036 Belvedere St. South, Sherbrooke, Québec, Canada J1H 4C4. Tel.: +18197802220x45670; fax: +18198297141.

References 

  1. Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, et al. IANA task force on nutrition and cognitive decline with aging. J. Nutr. Health Aging. 2007;11:132–152
  2. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch. Neurol. 2005;62:1849–1853
  3. Cunnane SC, Plourde M, Pifferi F, Bégin M, Féart C, Barberger P. Gateau fish, docosahexaenoic acid and Alzheimer’s disease. Prog. Lipid Res. 2009;48:239–256
  4. Caprari P, Scuteri A, Salvati AM, et al. Aging and red blood cell membrane: a study of centenarians. Exp. Gerontol. 1999;34:47–57
  5. Sands SA, Reid KJ, Windsor SL, Harris WS. The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes. Lipids. 2005;40:343–347
  6. Itomura M, Fujioka S, Hamazaki K, et al. Factors influencing EPA+DHA levels in red blood cells in Japan. In Vivo. 2008;22:131–135
  7. Rees D, Miles EA, Banerjee T, et al. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am. J. Clin. Nutr. 2006;83:331–342
  8. Vandal M, Freemantle E, Tremblay-Mercier J, et al. Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. Lipids. 2008;43:1085–1089
  9. Plourde M, Tremblay-Mercier J, Fortier M, Pifferi F, Cunnane SC. Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly. Nutrition. 2009;25:289–294
  10. Freemantle E, Vandal M, Tremblay Mercier J, Plourde M, Poirier J, Cunnane SC. Metabolic response to a ketogenic breakfast in the healthy elderly. J. Nutr. Health Aging. 2009;13:293–298
  11. Meydani M, Natiello F, Goldin B, et al. Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women. J. Nutr. 1991;121:484–491
  12. Plourde M, Cunnane SC. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl. Physiol. Nutr. Metab. 2007;32:619–634
  13. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch. Neurol. 2005;62:1849–1853
  14. Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr. 2006;83:S1467–S1476
  15. Whalley LJ, Deary IJ, Starr JM, et al. n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood. Am. J. Clin. Nutr. 2008;87:449–454
  16. M. Plourde, M.C. Vohl, M. Vandal, P. Couture, S. Lemieux, S.C. Cunnane, Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE 4 but not by the common PPAR-α L162V polymorphism in men, Brit. J. Nutr. 102 (2009) 1121–1124.

PII: S0952-3278(10)00054-2

doi: 10.1016/j.plefa.2010.02.010

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 277-280 , April 2010

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