Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 259-264 , April 2010

Fatty acid–genotype interactions and cardiovascular risk

  • Anne M. Minihane

      Affiliations

    • Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand
    • Hugh Sinclair Nutrition Group, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
    • Corresponding Author InformationCorresponding author at: Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand. Tel.: +6499231732; fax: +6493737499.

References 

  1. Armah CK, Jackson KG, Doman I, James L, Cheghani F, Minihane AM. Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin. Sci. (London). 2008;114:679–686
  2. Galli C, Calder PC. Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. Ann. Nutr. Metab. 2009;55:123–139
  3. Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis. 2008;197:12–24
  4. Harris WS, Mozaffarian D, Rimm E, et al. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation. 2009;119:902–907
  5. Miller GJ. Dietary fatty acids and the haemostatic system. Atherosclerosis. 2005;179:213–227
  6. Kris-Etherton P, Harris W, Appel L. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 2003;23:E31–E42
  7. Committee on Medical Aspects of Food Policy (COMA), Department of Health, Report of the Cardiovascular Review group, nutritional aspects of cardiovascular disease, RHSS 46, London: HMSO, 1994.
  8. Scientific Advisory Committee on Nutrition (SACN) and Committee on Toxicology (COT), Food Standards Agency and Department of Health, Advice on fish Consumption: Benefits and Risks. TSO (The Stationary Office), Norwich, UK, 2004.
  9. Rimbach G, Minihane AM. Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there. Proc. Nutr. Soc. 2009;
  10. Bauer F, Elbers CC, Adan RA, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am. J. Clin. Nutr. 2009;90:951–959
  11. Qi L, Kraft P, Hunter DJ, Hu FB. The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum. Mol. Genet. 2008;17:3502–3508
  12. Burdge GC. Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot. Essent. Fatty Acids. 2006;75:161–168
  13. Marquardt A, Stohr H, White K, Weber BH. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000;66:175–183
  14. Schaeffer L, Gohlke H, Muller M, et al. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum. Mol. Genet. 2006;15:1745–1756
  15. Baylin A, Ruiz-Narvaez E, Kraft P, Campos H. alpha-linolenic acid, delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. Am. J. Clin. Nutr. 2007;85:554–560
  16. Malerba G, Schaeffer L, Xumerle L, et al. SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids. 2008;43:289–299
  17. Martinelli N, Girelli D, Malerba G, et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am. J. Clin. Nutr. 2008;88:941–949
  18. Rzehak P, Heinrich J, Klopp N, et al. Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Br. J. Nutr. 2009;101:20–26
  19. Truong H, DiBello JR, Ruiz-Narvaez E, Kraft P, Campos H, Baylin A. Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome?. Am. J. Clin. Nutr. 2009;89:920–925
  20. Xie L, Innis SM. Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n−6) and (n−3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J. Nutr. 2008;138:2222–2228
  21. Aulchenko YS, Ripatti S, Lindqvist I, et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat. Genet. 2009;41:47–55
  22. Sabatti C, Service SK, Hartikainen AL, et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat. Genet. 2009;41:35–46
  23. Tanaka T, Shen J, Abecasis GR, et al. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI study. PLoS Genet. 2009;5:e1000338
  24. Dietrich M, Hu Y, Block G, et al. Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humans. Lipids. 2005;40:329–334
  25. Jofre-Monseny L, de Pascual-Teresa S, Plonka E, et al. Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages. Br. J. Nutr. 2007;97:864–871
  26. Jofre-Monseny L, Minihane AM, Rimbach G. Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol. Nutr. Food Res. 2008;52:131–145
  27. Minihane AM, Jofre-Monseny L, Olano-Martin E, Rimbach GH, Apolipoprotein E. genotype, cardiovascular risk and responsiveness to dietary fat manipulation. Proc. Nutr. Soc. 2007;66:183–197
  28. Singh P, Singh M, Mastana S. apoE distribution in world populations with new data from India and the UK. Ann. Hum. Biol. 2006;33:297–308
  29. Yang Y, Ruiz-Narvaez E, Kraft P, Campos H. Effect of apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica. Hum. Biol. 2007;79:637–647
  30. Loktionov A, Scollen S, McKeown N, Bingham SA. Gene-nutrient interactions: dietary behaviour associated with high coronary heart disease risk particularly affects serum LDL cholesterol in apolipoprotein E epsilon4-carrying free-living individuals. Br. J. Nutr. 2000;84:885–890
  31. Wu K, Bowman R, Welch AA, et al. Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study. Eur. Heart J. 2007;28:2930–2936
  32. Masson LF, McNeill G, Avenell A. Genetic variation and the lipid response to dietary intervention: a systematic review. Am. J. Clin. Nutr. 2003;77:1098–1111
  33. Ordovas JM. Genotype-phenotype associations: modulation by diet and obesity. Obesity. 16. Silver Spring; 2008;S40-6
  34. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106:2747–2757
  35. Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis. 2006;189:19–30
  36. Minihane AM, Khan S, Leigh-Firbank EC, et al. ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler. Thromb. Vasc. Biol. 2000;20:1990–1997
  37. Olano-Martin E, Anil E, Caslake MJ, et al. Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis. 2009;
  38. Caslake MJ, Miles EA, Kofler BM, et al. Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN study. Am. J. Clin. Nutr. 2008;88:618–629
  39. Minihane AM, Khan S, Talmud PJ, et al. Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP). Int. J. Obes. Relat. Metab. Disord. 2000;24:1097–1106
  40. Olano-Martin E, Abraham EC, Gill-Garrison R, et al. Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. J. Lipid Res. 2008;49:945–953
  41. Lindi V, Schwab U, Louheranta A, et al. Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n−3 fatty acid supplementation. Mol. Genet. Metab. 2003;79:52–60
  42. Madden J, Carrero JJ, Brunner A, et al. Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men. Prostaglandins Leukot. Essent. Fatty Acids. 2008;78:327–335
  43. Boekholdt SM, Kuivenhoven JA, Hovingh GK, Jukema JW, Kastelein JJ, van Tol A. CETP gene variation: relation to lipid parameters and cardiovascular risk. Curr. Opin. Lipidol. 2004;15:393–398
  44. Isaacs A, Sayed-Tabatabaei FA, Njajou OT, Witteman JC, van Duijn CM. The −514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. J. Clin. Endocrinol. Metab. 2004;89:3858–3863
  45. Ordovas JM, Corella D, Demissie S, et al. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham study. Circulation. 2002;106:2315–2321
  46. Tai ES, Corella D, Deurenberg-Yap M, et al. Dietary fat interacts with the −514 C>T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey. J. Nutr. 2003;133:3399–3408
  47. Nettleton JA, Steffen LM, Ballantyne CM, Boerwinkle E, Folsom AR. Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults. Atherosclerosis. 2007;194:e131–e140
  48. Zhang C, Lopez-Ridaura R, Rimm EB, Rifai N, Hunter DJ, Hu FB. Interactions between the −514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men. Am. J. Clin. Nutr. 2005;81:1429–1435
  49. Boekholdt SM, Sacks FM, Jukema JW, et al. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. Circulation. 2005;111:278–287
  50. Li TY, Zhang C, Asselbergs FW, et al. Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men. Am. J. Clin. Nutr. 2007;86:1524–1529
  51. Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA. 2007;298:309–316
  52. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299–308
  53. Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F, Ordovas JM. Influence of genetic factors in the modulation of postprandial lipemia. Atheroscler. Suppl. 2008;9:49–55
  54. Tai ES, Ordovas JM. Clinical significance of apolipoprotein A5. Curr. Opin. Lipidol. 2008;19:349–354
  55. Lai CQ, Corella D, Demissie S, et al. Dietary intake of n−6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham heart study. Circulation. 2006;113:2062–2070
  56. Cardona F, Guardiola M, Queipo-Ortuno MI, Murri M, Ribalta J, Tinahones FJ. The −1131 T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study. Atherosclerosis. 2009;206:148–152
  57. Lai CQ, Arnett DK, Corella D, et al. Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN study. Arterioscler. Thromb. Vasc. Biol. 2007;27:1417–1425
  58. Liu Y, Ordovas JM, Gao G, et al. Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study. Pharmacogenet. Genomics. 2009;19:161–169
  59. Harris WS, Bulchandani D. Why do omega-3 fatty acids lower serum triglycerides?. Curr. Opin Lipidol. 2006;17:387–393
  60. F. Drenos, J.C. Whittaker, S.E. Humphries, The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk, Ann. Hum. Genet. 71 (2007) 611–619.

PII: S0952-3278(10)00058-X

doi: 10.1016/j.plefa.2010.02.014

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 259-264 , April 2010

Article Tools

* Image Usage & Resolution