« Previous
Next »
Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4
, Pages 199-204
, April 2010
Conjugated linoleic acid and inflammatory cell signalling
References
- . Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. J. Lipid Res. 2001;42:1056–1061
- . Biological effects of conjugated linoleic acids in health and disease. J. Nutr. Biochem. 2006;17:789–810
- . Cis-9,trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma-related mechanism in mice. J. Nutr. 2008;138:1336–1342
- . Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J. Immunol. 2005;175:4990–4998
- . Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2. Br. J. Nutr. 2008;100:13–17
- . Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition. 2004;20:1008–1017
- . Conjugated linoleic acid (CLA) prevents body fat accumulation and weight gain in an animal model. J. Food Sci. 2007;72:S612–S617
- . Conjugated linoleic acid reduces body fat accretion and lipogenic gene expression in neonatal pigs fed low- or high-fat formulas. J. Nutr. 2008;138:449–454
- . Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am. J. Clin. Nutr. 2007;85:1203–1211
- . Intermediates and products of the biohydrogenation of linoleic acid by Butyrinvibrio fibrisolvens. J. Biol. Chem. 1966;241:1350–1354
- . Biosynthesis of conjugated linoleic acid (CLA): a review. Pak. J. Nutr. 2004;3:72–81
- . Variation of trans fatty acids in milk fats. Z. Ernahrungswiss. 1995;34:27–29
- . The role of Δ9-desaturase in the production of cis-9, trans-11 CLA and other Δ9- desaturated fatty acids in milk fat. J. Dairy Sci. 2001;83(suppl. 1):164
- . Trans-11-18: 1 is effectively Delta9-desaturated compared with trans-12–18: 1 in humans. Br. J. Nutr. 2006;95:752–761
- . Ip Ccis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in rats. J. Nutr. 2003;133:2893–2900
- . Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. J. Nutr. 2000;130:208–215
- . CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin. Nutr. 2006;25:454–465
- . Activation of PPAR [gamma] and [delta] by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology. 2004;127:777–791
- Y.K. Nakamura, N. Flintoff-Dye, Omaye S.T., Conjugated linoleic acid modulation of risk factors associated with atherosclerosis, Nutr. Metab. (London). (2008) 21;5:22.
- . Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis. 2006;187:40–49
- . Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice. Atherosclerosis. 2006;189:318–327
- . Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes. 2007;56:574–582
- G.V. Halade, M.M. Rahman, G. Fernandes, Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6 J mice, J. Nutr. Biochem. (2009) [Epub ahead of print].
- . Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Horm. IGF Res. 2008;18:361–368
- . Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats. Metabolism. 2007;56:1601–1611
- . Immunobiology of dendritic cells. Annu. Rev. Immunol. 2000;18:767–811
- . Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates Interleukin 10 production by dendritic cells : a novel strategy for evasion of protective T helper type 1 responses by bordetella pertussis. J. Exp. Med. 2002;195:221–231
- . Antigen-specific regulatory T cells — their induction and role in infection. Semin. Immunol. 2004;16:107–117
- . Riley EM: IL-10, the master regulator of immunity to infection. J. Immunol. 2008;180:5771–5777
- . Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. Arch. Anim. Nutr. 2005;59:429–438
- . The metabolic syndrome and cardiovascular disease: part 2. Prev. Cardiol. 2008;11:223–229
- . Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabet. Med. 2006;23:469–480
- . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87–91
- . Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes. Res. 2004;12:962–971
- . Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005;111:1448–1454
- . Inflammation and metabolic disorders. Nature. 2006;444:860–867
- . Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003;112:1796–1808
- . Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid. Res. 2005;46:2347–2355
- . Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J. Clin. Endocrinol. Metab. 2005;90:2282–2289
- . Effect of conjugated linoleic acid on body composition in mice. Lipids. 1997;32:853–858
- . Effects of the individual isomerscis-9,trans-11 vs. trans-10,cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B. Lipids. 2005;40:909–918
- . Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR[gamma]-dependent mechanism. Biochim. Biophys. Acta (BBA) — Mol. Cell Biol. Lipid. 2002;1581:89–99
- . Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. Br. Poult. Sci. 2003;44:203–210
- . NF-kappaB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid. Biochim. Biophys. Acta. 2006;1761:969–972
- . Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis. Physiol. Genomics. 2006;27:282–294
- . Dietary conjugated linoleic acid and body composition. Am. J. Clin. Nutr. 2004;79:1153S–1158S
- . Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. 1998;275:R667–R672
- . Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J. Lipid Res. 2002;43:1400–1409
- . Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. 2008;49:98–106
- . Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes. 2006;55:1634–1641
- H. Qin, Y. Liu, N. Lu, Y. Li, C.H. Sun, cis-9,trans-11-conjugated linoleic acid activates AMP-activated protein kinase in attenuation of insulin resistance in C(2)C(12) myotubes, J. Agric. Food Chem. (2009) (Epub ahead of print).
- . Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int. J. Obes. Relat. Metab. Disord. 2001;25:1129–1135
- . Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am. J. Clin. Nutr. 2004;80:887–89555
- . Atherosclerosis is an inflammatory disease. Am. Heart J. 1999;138:S419–S420
- . Macrophages: promising targets for the treatment of atherosclerosis. Curr. Vasc. Pharmacol. 2009;7:234–243
- . Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture. Curr. Vasc. Pharmacol. 2005;3:63–68
- . Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions. Lipids. 2004;39:611–616
- . Dietary fat and atherosclerosis. J. Nutr. Biochem. 2002;13:391
- . Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters. Lipids. 2006;41:41–48
- . Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice. Lipids. 2002;37:487–494
- . Rosiglitazone reduces the development and rupture of experimental aortic aneurysms. Circulation. 2009;119:3125–3132
- . Trans-10, cis-12- and cis-9, trans-11-conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice. J. Nutr. 2006;136:353–359
- . Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. FASEB J. 2005;19:1746–1748
- . The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. Eur. J. Clin. Nutr. 2005;59:742–750
- . Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am. J. Clin. Nutr. 2004;80:614–620
- . The effects of conjugated linoleic acid on human health-related outcomes. Proc. Nutr. Soc. 2005;64:171–182
- . Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. J. Nutr. 2001;131:1548–1554
- . Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia. 2004;47:1016–1019
- . Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr. 2004;80:279–283. Risk factors for the development of atherosclerosis in childhood and adolescence. Arq. Bras. Cardiol. 2008;90:276–283
- . An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women. J. Nutr. 2008;138:1445–1451
- . A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care. 2001;24:539–548
- . The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br. J. Nutr. 2002;88:243–251
- . Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males. J. Nutr. Biochem. 2007;18:658–666
- . Atherogenic effect of interleukin-2 and antiatherogenic effect of interleukin-2 antibody in apo-E-deficient mice. Angiology. 2004;55:289–294
- Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects. Br. J. Nutr. 2007;97:273–280
- . Conjugated linoleic acid increased C-reactive protein in human subjects. Br. J. Nutr. 2005;94:791–795
- . Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function. Lipids. 2001;36:669–674
- . Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur. J. Clin. Nutr. 2003;57:595–603
- Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am. J. Clin. Nutr. 2006;83:744–753
- . Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am. J. Clin. Nutr. 2004;80:1626
- . Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expression. Lipids. 2007;42:707–716
- . cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt. Carcinogenesis. 2007;28:363–371
- . NF-kappaB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid. Biochim. Biophys. Acta. 2006;1761:969–972
- . A mechanistic approach to understanding conjugated linoleic acid’s role in inflammation using murine models of rheumatoid arthritis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007;293:R669–R676
- . Immunomodulatory properties of conjugated linoleic acid. Am. J. Clin. Nutr. 2004;79:1199S–1206S
☆ Funding support: CMR was funded by the Food Institutional Research Measure, Department of Agriculture and Food, Ireland (Project Number: 5254). The authors have no financial conflict of interest.
PII: S0952-3278(10)00065-7
doi: 10.1016/j.plefa.2010.02.021
© 2010 Elsevier Ltd. All rights reserved.
« Previous
Next »
Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4
, Pages 199-204
, April 2010
