Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 199-204 , April 2010

Conjugated linoleic acid and inflammatory cell signalling

References 

  1. Banni S, Carta G, Angioni E, Murru E, Scanu P, Melis MP, et al. Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. J. Lipid Res. 2001;42:1056–1061
  2. Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G. Biological effects of conjugated linoleic acids in health and disease. J. Nutr. Biochem. 2006;17:789–810
  3. Jaudszus A, Krokowski M, Mockel P, Darcan Y, Avagyan A, Matricardi P, et al. Cis-9,trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma-related mechanism in mice. J. Nutr. 2008;138:1336–1342
  4. Loscher CE, Draper E, Leavy O, Kelleher D, Mills KH, Roche HM. Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J. Immunol. 2005;175:4990–4998
  5. Reynolds CM, Loscher CE, Moloney AP, Roche HM. Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2. Br. J. Nutr. 2008;100:13–17
  6. Choi JS, Jung MH, Park HS, Song J. Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition. 2004;20:1008–1017
  7. Park Y, Albright KJ, Storkson JM, Liu W, Pariza MW. Conjugated linoleic acid (CLA) prevents body fat accumulation and weight gain in an animal model. J. Food Sci. 2007;72:S612–S617
  8. Corl BA, Mathews Oliver SA, Lin X, Oliver WT, Ma Y, Harrell RJ, et al. Conjugated linoleic acid reduces body fat accretion and lipogenic gene expression in neonatal pigs fed low- or high-fat formulas. J. Nutr. 2008;138:449–454
  9. Whigham LD, Watras AC, Schoeller DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am. J. Clin. Nutr. 2007;85:1203–1211
  10. Kepler CR, Hirons KP, McNeill JJ, Tove SB. Intermediates and products of the biohydrogenation of linoleic acid by Butyrinvibrio fibrisolvens. J. Biol. Chem. 1966;241:1350–1354
  11. Khanal , Dhiman . Biosynthesis of conjugated linoleic acid (CLA): a review. Pak. J. Nutr. 2004;3:72–81
  12. Precht D. Variation of trans fatty acids in milk fats. Z. Ernahrungswiss. 1995;34:27–29
  13. Corl BA, Baumgard LH, Dwyer DA, Griinari JM, Phillips BS, Bauman DE. The role of Δ9-desaturase in the production of cis-9, trans-11 CLA and other Δ9- desaturated fatty acids in milk fat. J. Dairy Sci. 2001;83(suppl. 1):164
  14. Kuhnt K, Kraft J, Moeckel P, Jahreis G. Trans-11-18: 1 is effectively Delta9-desaturated compared with trans-12–18: 1 in humans. Br. J. Nutr. 2006;95:752–761
  15. Corl BA, Barbano DM, Bauman DE. Ip Ccis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in rats. J. Nutr. 2003;133:2893–2900
  16. Santora JE, Palmquist DL, Roehrig KL. Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. J. Nutr. 2000;130:208–215
  17. Bassaganya-Riera J, Hontecillas R. CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin. Nutr. 2006;25:454–465
  18. Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, Hennighausen L, Gonzalez F, et al. Activation of PPAR [gamma] and [delta] by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology. 2004;127:777–791
  19. Y.K. Nakamura, N. Flintoff-Dye, Omaye S.T., Conjugated linoleic acid modulation of risk factors associated with atherosclerosis, Nutr. Metab. (London). (2008) 21;5:22.
  20. Toomey S, Harhen B, Roche HM, Fitzgerald D, Belton O. Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis. 2006;187:40–49
  21. Arbones-Mainar JM, Navarro MA, Guzman MA, Arnal C, Surra JC, Acin S, et al. Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice. Atherosclerosis. 2006;189:318–327
  22. Moloney F, Toomey S, Noone E, Nugent A, Allan B, Loscher CE, et al. Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes. 2007;56:574–582
  23. G.V. Halade, M.M. Rahman, G. Fernandes, Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6 J mice, J. Nutr. Biochem. (2009) [Epub ahead of print].
  24. Zhou XR, Sun CH, Liu JR, Zhao D. Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Horm. IGF Res. 2008;18:361–368
  25. Noto A, Zahradka P, Yurkova N, Xie X, Truong H, Nitschmann E, et al. Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats. Metabolism. 2007;56:1601–1611
  26. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 2000;18:767–811
  27. McGuirk P, McCann C, Mills KH. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates Interleukin 10 production by dendritic cells : a novel strategy for evasion of protective T helper type 1 responses by bordetella pertussis. J. Exp. Med. 2002;195:221–231
  28. Mills KH, McGuirk P. Antigen-specific regulatory T cells — their induction and role in infection. Semin. Immunol. 2004;16:107–117
  29. Couper KN, Blount DG. Riley EM: IL-10, the master regulator of immunity to infection. J. Immunol. 2008;180:5771–5777
  30. Zhao L, Yin J, Li D, Lai C, Chen X, Ma D. Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. Arch. Anim. Nutr. 2005;59:429–438
  31. Jiamsripong P, Mookadam M, Alharthi MS, Khandheria BK, Mookadam F. The metabolic syndrome and cardiovascular disease: part 2. Prev. Cardiol. 2008;11:223–229
  32. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabet. Med. 2006;23:469–480
  33. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87–91
  34. Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, et al. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes. Res. 2004;12:962–971
  35. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005;111:1448–1454
  36. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867
  37. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003;112:1796–1808
  38. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid. Res. 2005;46:2347–2355
  39. Bruun JM, Lihn AS, Pedersen SB, Richelsen B. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J. Clin. Endocrinol. Metab. 2005;90:2282–2289
  40. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids. 1997;32:853–858
  41. Ramakers JD, Plat J, Sébédio JL, Mensink RP. Effects of the individual isomerscis-9,trans-11 vs. trans-10,cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B. Lipids. 2005;40:909–918
  42. Yu Y, Correll PH, Vanden Heuvel JP. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR[gamma]-dependent mechanism. Biochim. Biophys. Acta (BBA) — Mol. Cell Biol. Lipid. 2002;1581:89–99
  43. Politis I, Dimopoulou M, Voudouri A, Noikokyris P, Feggeros K. Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. Br. Poult. Sci. 2003;44:203–210
  44. Li G, Dong B, Butz DE, Park Y, Pariza MW, Cook ME. NF-kappaB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid. Biochim. Biophys. Acta. 2006;1761:969–972
  45. LaRosa PC, Miner J, Xia Y, Zhou Y, Kachman S, Fromm ME. Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis. Physiol. Genomics. 2006;27:282–294
  46. Wang Y, Jones PJ. Dietary conjugated linoleic acid and body composition. Am. J. Clin. Nutr. 2004;79:1153S–1158S
  47. West DB, Delany JP, Camet PM, Blohm F, Truett AA, Scimeca J. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. 1998;275:R667–R672
  48. Clément L, Poirier H, Niot I, Bocher V, Guerre-Millo M, Krief S, et al. Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J. Lipid Res. 2002;43:1400–1409
  49. Wendel AA, Purushotham A, Liu LF, Belury MA. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. 2008;49:98–106
  50. Poirier H, Shapiro JS, Kim RJ, Lazar MA. Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes. 2006;55:1634–1641
  51. H. Qin, Y. Liu, N. Lu, Y. Li, C.H. Sun, cis-9,trans-11-conjugated linoleic acid activates AMP-activated protein kinase in attenuation of insulin resistance in C(2)C(12) myotubes, J. Agric. Food Chem. (2009) (Epub ahead of print).
  52. Risérus U, Berglund L, Vessby B. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int. J. Obes. Relat. Metab. Disord. 2001;25:1129–1135
  53. Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am. J. Clin. Nutr. 2004;80:887–89555
  54. Ross R. Atherosclerosis is an inflammatory disease. Am. Heart J. 1999;138:S419–S420
  55. Wilson HM, Barker RN, Erwig LP. Macrophages: promising targets for the treatment of atherosclerosis. Curr. Vasc. Pharmacol. 2009;7:234–243
  56. Boyle JJ. Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture. Curr. Vasc. Pharmacol. 2005;3:63–68
  57. Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson TA, Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions. Lipids. 2004;39:611–616
  58. Kritchevsky D. Dietary fat and atherosclerosis. J. Nutr. Biochem. 2002;13:391
  59. Wilson TA, Nicolosi RJ, Saati A, Kotyla T, Kritchevsky D. Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters. Lipids. 2006;41:41–48
  60. Zuckerman SH, Kauffman RF, Evans GF. Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice. Lipids. 2002;37:487–494
  61. Jones A, Deb R, Torsney E, Howe F, Dunkley M, Gnaneswaran Y, et al. Rosiglitazone reduces the development and rupture of experimental aortic aneurysms. Circulation. 2009;119:3125–3132
  62. Arbonés-Mainar JM, Navarro MA, Acín S, Guzmán MA, Arnal C, Surra JC, et al. Trans-10, cis-12- and cis-9, trans-11-conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice. J. Nutr. 2006;136:353–359
  63. de Roos B, Rucklidge G, Reid M, Ross K, Duncan G, Navarro MA, et al. Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. FASEB J. 2005;19:1746–1748
  64. Nugent AP, Roche HM, Noone EJ, Long A, Kelleher DK, Gibney MJ. The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. Eur. J. Clin. Nutr. 2005;59:742–750
  65. Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Jones EL, et al. Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am. J. Clin. Nutr. 2004;80:614–620
  66. Tricon S, Burdge GC, Williams CM, Calder PC, Yaqoob P. The effects of conjugated linoleic acid on human health-related outcomes. Proc. Nutr. Soc. 2005;64:171–182
  67. Ritzenthaler KL, McGuire MK, Falen R, Shultz TD, Dasgupta N, McGuire MA. Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. J. Nutr. 2001;131:1548–1554
  68. Risérus U, Vessby B, Arner P, Zethelius B. Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia. 2004;47:1016–1019
  69. Risérus U, Vessby B, Arnlöv J, Basu S. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr. 2004;80:279–283Santos MG, Pegoraro M, Sandrini F, Macuco EC. Risk factors for the development of atherosclerosis in childhood and adolescence. Arq. Bras. Cardiol. 2008;90:276–283
  70. Tholstrup T, Raff M, Straarup EM, Lund P, Basu S, Bruun JM. An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women. J. Nutr. 2008;138:1445–1451
  71. Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care. 2001;24:539–548
  72. Noone EJ, Roche HM, Nugent AP, Gibney MJ. The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br. J. Nutr. 2002;88:243–251
  73. Mullen A, Moloney F, Nugent AP, Doyle L, Cashman KD, Roche HM. Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males. J. Nutr. Biochem. 2007;18:658–666
  74. Upadhya S, Mooteri S, Peckham N, Pai RG. Atherogenic effect of interleukin-2 and antiatherogenic effect of interleukin-2 antibody in apo-E-deficient mice. Angiology. 2004;55:289–294
  75. Nazare JA, de la Perriere AB, Bonnet F, Desage M, Peyrat J, Maitrepierre C, et al Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects. Br. J. Nutr. 2007;97:273–280
  76. Smedman A, Basu S, Jovinge S, Fredrikson GN, Vessby B. Conjugated linoleic acid increased C-reactive protein in human subjects. Br. J. Nutr. 2005;94:791–795
  77. Kelley DS, Simon VA, Taylor PC, Rudolph IL, Benito P, Nelson GJ, et al. Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function. Lipids. 2001;36:669–674
  78. Albers R, van der Wielen RP, Brink EJ, Hendriks HF, Dorovska-Taran VN, Mohede IC. Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur. J. Clin. Nutr. 2003;57:595–603
  79. Tricon S, Burdge GC, Jones EL, Russell JJ, El-Khazen S, Moretti E, et al Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am. J. Clin. Nutr. 2006;83:744–753
  80. Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, et al. Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am. J. Clin. Nutr. 2004;80:1626
  81. Stachowska E, Baskiewicz-Masiuk M, Dziedziejko V, Adler G, Bober J, Machalinski B, et al. Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expression. Lipids. 2007;42:707–716
  82. Hwang DM, Kundu JK, Shin JW, Lee JC, Lee HJ, Surh YJ. cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt. Carcinogenesis. 2007;28:363–371
  83. Li G, Dong B, Butz DE, Park Y, Pariza MW, Cook ME. NF-kappaB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid. Biochim. Biophys. Acta. 2006;1761:969–972
  84. Butz DE, Li G, Huebner SM, Cook ME. A mechanistic approach to understanding conjugated linoleic acid’s role in inflammation using murine models of rheumatoid arthritis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007;293:R669–R676
  85. O'Shea M, Bassaganya-Riera J, Mohede IC. Immunomodulatory properties of conjugated linoleic acid. Am. J. Clin. Nutr. 2004;79:1199S–1206S

 Funding support: CMR was funded by the Food Institutional Research Measure, Department of Agriculture and Food, Ireland (Project Number: 5254). The authors have no financial conflict of interest.

PII: S0952-3278(10)00065-7

doi: 10.1016/j.plefa.2010.02.021

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 199-204 , April 2010