Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 155-158 , April 2010

n-3 Polyunsaturated fatty acids—Physiological relevance of dose

  • Wooki Kim

      Affiliations

    • Program in Integrative Nutrition & Complex Diseases, Texas A&M University, College Station, TX 77843, USA
    • Intercollegiate Faculty of Nutrition, Texas A&M University, College Station, TX 77843, USA
    • ,
  • David N. McMurray

      Affiliations

    • Intercollegiate Faculty of Nutrition, Texas A&M University, College Station, TX 77843, USA
    • Center for Environmental and Rural Health, Texas A&M University, College Station, TX 77843, USA
    • Department of Microbial & Molecular Pathogenesis, Texas A&M University Health Science Center, College Station, TX 77843, USA
    • ,
  • Robert S. Chapkin

      Affiliations

    • Program in Integrative Nutrition & Complex Diseases, Texas A&M University, College Station, TX 77843, USA
    • Intercollegiate Faculty of Nutrition, Texas A&M University, College Station, TX 77843, USA
    • Center for Environmental and Rural Health, Texas A&M University, College Station, TX 77843, USA
    • Vegetable & Fruit Improvement Center, Texas A&M University, College Station, TX 77843, USA
    • Corresponding Author InformationCorrespondence to: Room 321, Kleberg Biotechnology Center, MS 2253, Texas A&M University, College Station, TX 77843-2253, USA. Tel.: +19798450419; fax: +19798622378.

References 

  1. Stone NJ. Fish consumption, fish oil, lipids, and coronary heart disease. Circulation. 1996;94:2337–2340
  2. Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am. J. Med. 2002;112:298–304
  3. Lupton JR, Chapkin RS. Chemopreventive effects of omega-3 fatty acids. In:  Kelloff GJ,  Hawk ET,  Sigman CC editor. Cancer Chemo Prevention; Vol I: Promising Cancer Chemopreventive Agents. Totowa, NJ: Humana Press; 2004;p. 591–608
  4. Augustsson K, Michaud DS, Rimm EB, Leitzmann MF, Stampfer MJ, Willett WC, et al. A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiol. Biomarkers Prev. 2003;12:64–67
  5. Caygill CP, Hill MJ. Fish, n-3 fatty acids and human colorectal and breast cancer mortality. Eur. J. Cancer Prev. 1995;4:329–332
  6. Chapkin RS, McMurray DN, Davidson LA, Patil BS, Fan YY, Lupton JR. Bioactive dietary long-chain fatty acids: emerging mechanisms of action. Br. J. Nutr. 2008;100:1152–1157
  7. Jia Q, Lupton JR, Smith R, Weeks BR, Callaway E, Davidson LA, et al. Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Res. 2008;68:3985–3991
  8. Chapkin RS, Kim W, Lupton JR, McMurray DN. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. Prostaglandins Leukot. Essent. Fatty Acids. 2009;81:187–191
  9. Kelley DS. Modulation of human immune and inflammatory responses by dietary fatty acids. Nutrition. 2001;17:669–673
  10. Mehta LR, Dworkin RH, Schwid SR. Polyunsaturated fatty acids and their potential therapeutic role in multiple sclerosis. Nat. Clin. Pract. Neurol. 2009;5:82–92
  11. Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J. Neurosci. 2007;27:4385–4395
  12. Kolar SS, Barhoumi R, Lupton JR, Chapkin RS. Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. Cancer Res. 2007;67:5561–5568
  13. Switzer KC, Fan YY, Wang N, McMurray DN, Chapkin RS. Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in Th1-polarized murine CD4+ T-cells. J. Lipid Res. 2004;45:1482–1492
  14. Zhang P, Kim W, Zhou L, Wang N, Ly LH, McMurray DN, et al. Dietary fish oil inhibits antigen-specific murine Th1 cell development by suppression of clonal expansion. J. Nutr. 2006;136:2391–2398
  15. Ackman RG. The absorption of fish oils and concentrates. Lipids. 1992;27:858–862
  16. Sadou H, Leger CL, Descomps B, Barjon JN, Monnier L, Crastes de Paulet A. Differential incorporation of fish-oil eicosapentaenoate and docosahexaenoate into lipids of lipoprotein fractions as related to their glyceryl esterification: a short-term (postprandial) and long-term study in healthy humans. Am. J. Clin. Nutr. 1995;62:1193–1200
  17. Christensen MS, Hoy CE, Redgrave TG. Lymphatic absorption of n-3 polyunsaturated fatty acids from marine oils with different intramolecular fatty acid distributions. Biochim. Biophys. Acta. 1994;1215:198–204
  18. Elvevoll EO, Barstad H, Breimo ES, Brox J, Eilertsen KE, Lund T, et al. Enhanced incorporation of n-3 fatty acids from fish compared with fish oils. Lipids. 2006;41:1109–1114
  19. De Schrijver R, Vermeulen D, Backx S. Digestion and absorption of free and esterified fish oil fatty acids in rats. Lipids. 1991;26:400–404
  20. Hamam F, Shahidi F. Synthesis of structured lipids containing medium-chain and omega-3 fatty acids. J. Agric. Food Chem. 2006;54:4390–4396
  21. Cansell M, Nacka F, Combe N. Marine lipid-based liposomes increase in vivo FA bioavailability. Lipids. 2003;38:551–559
  22. Conquer JA, Holub BJ. Effect of supplementation with different doses of DHA on the levels of circulating DHA as non-esterified fatty acid in subjects of Asian Indian background. J. Lipid Res. 1998;39:286–292
  23. Kris-Etherton PM, Taylor DS, Yu-Poth S, Huth P, Moriarty K, Fishell V, et al. Polyunsaturated fatty acids in the food chain in the United States. Am. J. Clin. Nutr. 2000;71:179S–188S
  24. Rees D, Miles EA, Banerjee T, Wells SJ, Roynette CE, Wahle KW, et al. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am. J. Clin. Nutr. 2006;83:331–342
  25. Kelley DS, Taylor PC, Nelson GJ, Mackey BE. Dietary docosahexaenoic acid and immunocompetence in young healthy men. Lipids. 1998;33:559–566
  26. Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC. Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. J. Nutr. 2001;131:1918–1927
  27. Kelley DS, Taylor PC, Nelson GJ, Schmidt PC, Ferretti A, Erickson KL, et al. Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. Lipids. 1999;34:317–324
  28. Damsgaard CT, Frokiaer H, Lauritzen L. The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. Br. J. Nutr. 2008;99:147–154
  29. Feskens EJ, Kromhout D. Epidemiologic studies on Eskimos and fish intake. Ann. N Y Acad. Sci. 1993;683:9–15
  30. Nagata C, Takatsuka N, Shimizu H. Soy and fish oil intake and mortality in a Japanese community. Am. J. Epidemiol. 2002;156:824–831
  31. Okuyama H, Kobayashi T, Watanabe S. Dietary fatty acids—the N-6/N-3 balance and chronic elderly diseases. Excess linoleic acid and relative N-3 deficiency syndrome seen in Japan. Prog. Lipid Res. 1996;35:409–457
  32. Leslie CA, Gonnerman WA, Ullman MD, Hayes KC, Franzblau C, Cathcart ES. Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice. J. Exp. Med. 1985;162:1336–1349
  33. Fan YY, Kim W, Callaway E, Smith R, Jia Q, Zhou L, et al. Fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cells. Prostaglandins Leukot. Essent. Fatty Acids. 2008;79:209–214
  34. Li Q, Wang M, Tan L, Wang C, Ma J, Li N, et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts. J. Lipid. Res. 2005;46:1904–1913

☆ Supported by USDA 2008-34402-19195 Vegetable & Fruit Improvement Center, NIH Grants DK071707, CA59034 and P30ES09106.

PII: S0952-3278(10)00072-4

doi: 10.1016/j.plefa.2010.02.028

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 82, Issue 4 , Pages 155-158 , April 2010

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