Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 1 , Pages 1-8 , July 2010

The association of fatty acid deficiency symptoms (FADS) with actual essential fatty acid status in cheek cells

  • A. Kirby

      Affiliations

    • The Dyscovery Centre, Allt-yr-yn Campus, University of Wales, Newport NP20 5DA, UK
  • ,
  • A. Woodward

      Affiliations

    • The Dyscovery Centre, Allt-yr-yn Campus, University of Wales, Newport NP20 5DA, UK
  • ,
  • S. Jackson

      Affiliations

    • The Dyscovery Centre, Allt-yr-yn Campus, University of Wales, Newport NP20 5DA, UK
    • Corresponding Author InformationCorresponding author. Tel.: +441633432330; fax: +441633432331.
  • ,
  • Y. Wang

      Affiliations

    • Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, UK
  • ,
  • M.A. Crawford

      Affiliations

    • Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, UK

Received 22 December 2009 ,Revised 22 February 2010 ,Accepted 24 February 2010.

References 

  1. Chalon S, Vancassel S, Zimmer L, Guilloteau D, Durand G. Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission. Lipids. 2001;36:937–944
  2. Horrobin D. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Schizophr. Res. 1998;30:193–208
  3. Peet M, Murphy B, Shay J, Horrobin D. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol. Psychiatry. 1998;43:315–319
  4. Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty-acid levels in hyperactive-children. Clin. Pediatr. 1987;26:406–411
  5. Stevens L, Zentall SS, Abate ML, Kuczek T, Burgess JR. Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol. Behav. 1996;59:915–920
  6. Stevens L, Zhang W, Peck L, et al. EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviours. Lipids. 2003;38:1007–1021
  7. Bell JG, Sargent JR, Tocher DR, Dick JR. Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?. Prostaglandins Leukot. Essent. Fatty Acids. 2000;63:21–25
  8. Burr J, Burr M. On the nature and role of the fatty acids essential in nutrition. J. Biol. Chem. 1930;86:587–621
  9. Reisbick S, Neuringer M, Connor WE, Iliff-Sizemore S. Increased intake of water and NaCl solutions in omega-3 fatty acid deficient monkeys. Physiol. Behav. 1991;49:1139–1146
  10. Reisbick S, Neuringer M, Hasnain R, Connor WE. Polydipsia in rhesus monkeys deficient in omega-3 fatty acids. Physiol. Behav. 1990;47:315–323
  11. Huang SY, Yang HT, Chiu CC, Pariante CM, Su KP. Omega-3 fatty acids on the forced-swimming test. J. Psychiatr. Res. 2008;42:58–63
  12. Reisbick S, Neuringer M, Hasnain R, Connor WE. Home cage behavior of rhesus monkeys with long-term deficiency of omega-3 fatty acids. Physiol. Behav. 1994;55:231–239
  13. Bjerve KS, Mostad IL, Thoresen L. Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. Am. J. Clin. Nutr. 1987;45:66–77
  14. Hansen AE, Haggard DME, Boelsche AN, Adam DJ, Wiese HF. Essential fatty acids in infant nutrition III. Clinical manifestations of linoleic acid deficiency. J. Nutr. 1958;66:565–576
  15. Colquhoun I, Bunday S. A lack of essential fatty-acids as a possible cause of hyperactivity in children. Med. Hypotheses. 1981;7:673–679
  16. Antalis CJ, Stevens LJ, Campbell M, Pazdro R, Ericson K, Burgess JR. Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins Leukot. Essent. Fatty Acids. 2006;75:299–308
  17. Stevens LJ, Zentall SS, Deck JL, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am. J. Clin. Nutr. 1995;62:761–768
  18. Baker SM. A biochemical approach to the problem of dyslexia. J. Learn. Disabil. 1985;18:581–584
  19. Richardson AJ, Calvin CM, Clisby C, et al. Fatty acid deficiency signs predict the severity of reading and related difficulties in dyslexic children. Prostaglandins Leukot. Essent. Fatty Acids. 2000;63:69–74
  20. Taylor KE, Higgins CJ, Calvin CM, et al. Dyslexia in adults is associated with clinical signs of fatty acid deficiency. Prostaglandins Leukot. Essent. Fatty Acids. 2000;63:75–78
  21. Bell JG, MacKinlay EE, Dick JR, MacDonald DJ, Boyle RM, Glen ACA. Essential fatty acids and phospholipase A(2) in autistic spectrum disorders. Prostaglandins Leukot. Essent. Fatty Acids. 2004;71:201–204
  22. Burgess JR, Stevens L, Zhang W, Peck L. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am. J. Clin. Nutr. 2000;71:327–330
  23. Chen JR, Hsu SF, Hsu CD, Hwang LH, Yang SC. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J. Nutr. Biochem. 2004;15:467–472
  24. Mitchell EA, Lewis S, Cutler DR. Essential fatty acids and maladjusted behaviour in children. Prostaglandins Leukot. Med. 1983;12:281–287
  25. A. Kirby, A. Woodward, S. Jackson, Benefits of omega-3 supplementation for schoolchildren: review of the current evidence, Br. Educ. Res. J. First published on: 24 July 2009(iFirst).
  26. Sinn N. Physical fatty acid deficiency signs in children with ADHD symptoms. Prostaglandins Leukot. Essent. Fatty Acids. 2007;77:109–115
  27. Connor SL, Zhu N, Anderson GJ, et al. Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma and red blood cells. Am. J. Clin. Nutr. 2000;71:21–27
  28. Hoffman DR, Birch EE, Birch DG, Uauy R. Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. Lipids. 1999;34:337–342
  29. Morgan O, Baker A. Measuring deprivation in England and Wales using 2001 Carstairs scores. Health Stat. Q. 2006;31:28–33
  30. Centers for Disease Control and Prevention, BMI percentile calculator for child and teen english version, Retrieved July 30, 2008, from 〈http://apps.nccd.cdc.gov/dnpabmi/〉.
  31. J. Swanson, W. Nolan, W.E. Pelham, SNAP rating scale, Educational Resources Information Center (ERIC), 2001.
  32. Goodman R. The strengths and difficulties questionnaire: a research note. J. Child Psychol. Psychiatry. 1997;38:581–586
  33. Wilson BN, Kaplan BJ, Crawford SG, Campbell A, Dewey D. Reliability and validity of a parent questionnaire on childhood motor skills. Am. J. Occup. Ther. 2000;54:484–493
  34. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1957;226:497–509
  35. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br. J. Nutr. 2002;88:411–420
  36. Childs CE, Romeu-Nadal M, Burdge GC, Calder PC. Gender differences in the n-3 fatty acid content of tissues. Proc. Nutr. Soc. 2008;67:19–27
  37. Holman RT, Smythe L, Johnson S. Effect of sex and age on fatty acid composition of human serum lipids. Am. J. Clin. Nutr. 1979;32:2390–2399
  38. Yehuda S, Rabinovitz S, Mostofsky DI. Essential fatty acids and sleep: mini-review and hypothesis. Med. Hypotheses. 1998;50:139–145
  39. Alexander JW. Immunonutrition: the role of ω-3 fatty acids. Nutrition. 1998;14:627–633
  40. Miles EA, Calder PC. Modulation of immune function by dietary fatty acids. Proc. Nutr. Soc. 1998;57:277–292
  41. Scheinfield N, Dahdah MJ, Scher R. Vitamins and minerals: their role in nail heath and disease. J. Drugs Dermatol. 2007;6:782–787
  42. Lapillonne A, DeMar JC, Nannegari V, Heird WC. The fatty acid profile of buccal cheek cell phospholipids is a noninvasive marker of long-chain polyunsaturated fatty acid status in piglets. J. Nutr. 2002;132:2319–2323
  43. Arnold LE, DiSilvestro RA. Zinc in attention-deficit/hyperactivity disorder. J. Child Adolesc. Psychopharmacol. 2005;15:619–627
  44. Bilici M, Yildirim F, Kandil S, et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2004;28:181–190

 Sources of support: This research was undertaken as part of a larger study financially supported by a grant from Seven Seas Ltd. No authors report a conflict of interest.

PII: S0952-3278(10)00079-7

doi: 10.1016/j.plefa.2010.02.035

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 1 , Pages 1-8 , July 2010