Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 2 , Pages 83-88, August 2010

Low-dose arachidonic acid intake increases erythrocytes and plasma arachidonic acid in young women

  • Satoko Hirota

      Affiliations

    • Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan
    • Corresponding Author InformationCorresponding author. Tel./fax: +81492823284
    • ,
  • Naoko Adachi

      Affiliations

    • Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan
    • ,
  • Toshiharu Gomyo

      Affiliations

    • Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan
    • ,
  • Hiroshi Kawashima

      Affiliations

    • Institute for Health Care Science, Suntory Wellness Ltd., 1-1-1 Wakayamadai, Shimamoto, Osaka 618-8503, Japan
    • ,
  • Yoshinobu Kiso

      Affiliations

    • Institute for Health Care Science, Suntory Wellness Ltd., 1-1-1 Wakayamadai, Shimamoto, Osaka 618-8503, Japan
    • ,
  • Terue Kawabata

      Affiliations

    • Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan

Received 10 January 2010; received in revised form 13 April 2010; accepted 14 May 2010. published online 28 June 2010.

Abstract 

Arachidonic acid (ARA) is considered to be a minor contributor to the diet. Previous reports regarding the effect of ARA supplementation on the composition of long-chain polyunsaturated fatty acids (LCPUFA) in the blood of humans are extremely limited. In the present study, we conducted a crossover double-blind, placebo-control study. Twenty-three young Japanese women consumed one capsule containing triacylglycerol enriched with 80mg ARA, equivalent to the amount in one egg, daily for 3 weeks. Blood samples were drawn before and after treatment periods, and the compositions of the LCPUFA in blood lipid fractions were measured. The supplementation of ARA increased the composition of ARA, but did not decrease the composition of n-3LCPUFA in erythrocyte phospholipids and plasma phospholipids, esterified cholesterol, and triacylglycerol. We found that dietary ARA increased the ARA level in all lipid fractions of the blood, even at a very low dose.

Keywords: Arachidonic acid, Young women, Low dose intake, Erythrocyte membrane, Fatty acid composition

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PII: S0952-3278(10)00108-0

doi:10.1016/j.plefa.2010.05.003

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 2 , Pages 83-88, August 2010

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