Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 3 , Pages 161-169, September 2010

Erythrocyte fatty acids and prostate cancer risk: A comparison of methods☆

  • J. Shannon

      Affiliations

    • Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA
    • Portland Veterans Affairs Medical Center, 2710 US Veterans Hospital Road, Portland, OR 97239-9823, USA
    • Corresponding Author InformationCorresponding author at: Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.
    • ,
  • J. O’Malley

      Affiliations

    • Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA
    • ,
  • M. Mori

      Affiliations

    • Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA
    • ,
  • M. Garzotto

      Affiliations

    • Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA
    • Portland Veterans Affairs Medical Center, 2710 US Veterans Hospital Road, Portland, OR 97239-9823, USA
    • ,
  • A.J. Palma

      Affiliations

    • Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA
    • Portland Veterans Affairs Medical Center, 2710 US Veterans Hospital Road, Portland, OR 97239-9823, USA
    • ,
  • I.B. King

      Affiliations

    • Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98101, USA

Received 4 December 2009; received in revised form 11 June 2010; accepted 24 June 2010. published online 15 July 2010.

Abstract 

The role of fatty acids (FA) in prostate carcinogenesis is unclear. Interest in the inter-relationship among different types of FA has resulted in new analytic approaches to FA and their role in cancer development.

We evaluated the association between erythrocyte FA and prostate cancer in 127 prostate cancer patients and 183 screen negative controls. We present three approaches to the analyses of the FA and prostate cancer association; (1) individual or common groups of FA, (2) biologically meaningful FA ratios and (3) principal components analysis.

Monounsaturated FA and the alpha-linolenic:eicosapentaenoic ratio were associated with reduced risk of prostate cancer. However, Factor 1, which was strongly correlated with some long chain saturated FA, was associated with an increased risk of prostate cancer.

We provide an example of modeling FA and their inter-relationships on the risk of prostate cancer. Comparing three approaches suggests the importance of considering the impact of the entire fatty acid profile in disease prevention.

Keywords: Fatty acids, Prostate cancer, Principal components analysis

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ Work Supported by: United States Public Health Service grants (5 M01 RR000334), (1 UL1 RR024120-01) and (K22CA94973) and was supported by the resources and facilities of the Portland Veterans Affairs Medical Center. Biostatistics support was provided through the Knight Cancer Institute Biostatistics Shared Resource (P30 CA069533-09) and the Oregon Clinical and Translational Research Institute (UL1 RR024140).

PII: S0952-3278(10)00112-2

doi:10.1016/j.plefa.2010.06.003

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 3 , Pages 161-169, September 2010

Article Tools

* Image Usage & Resolution