Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 3 , Pages 137-141 , September 2010

Bioavailability of marine n-3 fatty acid formulations

  • J. Dyerberg

      Affiliations

    • Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    • Corresponding Author InformationCorrespondence to: Lille Fredensvej 6A, DK 2920, Charlottenlund, Denmark. Tel.: +4539636688; fax: +4539636689.
    • ,
  • P. Madsen

      Affiliations

    • Department of Clinical Biochemistry, Center for Cardiovascular Research Aalborg Hospital, Aalborg, Denmark
    • ,
  • J.M. Møller

      Affiliations

    • Department of Gastroenterology, Aalborg Hospital, Aalborg, Denmark
    • ,
  • I. Aardestrup

      Affiliations

    • Department of Clinical Biochemistry, Center for Cardiovascular Research Aalborg Hospital, Aalborg, Denmark
    • ,
  • E.B. Schmidt

      Affiliations

    • Department of Cardiology, Center for Cardiovascular Research Aalborg Hospital, Aalborg, Denmark

Received 3 March 2010 ,Revised 28 June 2010 ,Accepted 29 June 2010.

References 

  1. Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet ii. 1979;433–435
  2. Dyerberg J, Bang HO, Stoffersen E, Moncada S, Vane JR. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet ii. 1978;117–119
  3. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106:2747–2757
  4. He K, Song Y, Daviglus ML, Liu K, van Horn L, Dyer AR, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation. 2004;109:2705–2711
  5. Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006;296:1885–1899
  6. Schmidt EB, Arnesen H, de Caterina R, Rasmussen LH, Kristensen SD. Marine n-3 polyunsaturated fatty acids and coronary heart disease. Part I. Background, epidemiology, animal data, effects on risk factors and safety. Thromb. Res. 2005;115:163–170
  7. Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA. 2010;303:250–257
  8. Ackman RG. The absorption of fish oils and concentrates. Lipids. 1992;27:858–862
  9. el Boustani S, Colette C, Monnier L, Descomps B, Crastes de Paulet A, Mendy F F. Enteral absorption in man of eicosapentaenoic acid in different chemical forms. Lipids. 1987;22:711–714
  10. Lawson LD, Hughes C. Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters. Biochim. Biophys. Res. Commun. 1988;152:328–335
  11. Luley C, Wieland H, Gruwald J. Bioavailability of omega-3 fatty acids: ethylester preparations are as suitable as triglyceride preparations. Akt. Ernaehr-Med. 1990;15:122–125
  12. Nordøy A, Barstad L, Connor WE, Hatcher L. Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am. J. Clin. Nutr. 1991;53:1185–1190
  13. Krokan HE, Bjerve KS, Mørk E. The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glycerol esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. Biochim. Biophys. Acta. 1993;1168:59–67
  14. Hansen J-B, Olsen J-O, Wilsgaard L, Lyngmo V, Svensson B B. Comparative effects of prolonged intake of highly purified fish oils as ethyl ester or triglyceride on lipids, haemostasis and platelet function in normolipaemic men. Eur. J. Clin. Nutr. 1993;47:497–507
  15. Blich EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959;37:911–917
  16. Kaluzny MA, Duncan LA, Merritt MV, Epps DE. Rapid separation of lipid classes in high yield and purity using bonded phase columns. J. Lipid Res. 1985;26:135–140
  17. Christie WW. Gas Chromatography and Lipids: A Practical Guide.. Ayr, Scotland: The Oily Press Ltd; 1989;
  18. Wallace JM, McCabe AJ, Robson PJ, Keogh MK, Murray CA, Kelly PM, et al. Bioavailability of n-3 polyunsaturated fatty acids (PUFA) in foods enriched with microencapsulated fish oil. Ann. Nutr. Metab. 2000;44:157–162
  19. Harris WS, Zucker ML, Dujovne CA. Omega-3 fatty acids in hypertriglyceridemic patients: triglycerides vs methyl esters. Am. J. Clin. Nutr. 1988;48:992–997
  20. Harris WS, Pottala JV, Sands SA, Jones PG. Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids. Am. J. Clin. Nutr. 2007;86:1621–1625
  21. Beckermann B, Beneke M, Seitz I. Vergleich der Bioverfügbarkeit von Eicosapentaensäure und Docosahexaensäure aus Triglyceriden, freien Feitsäuren undEthylestern hei Probanden. Arzneim. Forsch. Drug Res. 1990;40:700–704
  22. de Schrijver R, Vermeulen D, Backx S. Digestion and absorption of free and esterified fish oil fatty acids in rats. Lipids. 1991;26:400–404
  23. Lawson LD, Hughes BG. Absorption of eicosapentaenoic acid and docosahexaenoic acid from fish oil triacyiglycerols or fish oil ethyl esters co-ingested with a high-fat meal. Biochim. Biophys. Res. Commun. 1988;156:960–963
  24. Nelson GJ, Ackman RG. Absorption and transport of fat in mammals with emphasis on n-3 polyunsaturated fatty acids. Lipids. 1988;23:1005–1014
  25. Tso P, Hayashi H. The physiology and regulation of the intestinal absorption and transport of omega-3 and omega-6 fatty acids. Adv. Prostaglandin Thromboxane Leukotriene Res. 1989;19:623–626
  26. Borgström B. Fat digestion and absorption. In:  Smyth DH editors. Biomembranes. Vol. 4B:New York: Plenum Press; 1974;p. 555–620
  27. Christensen MS, Høy C-E, Redgrave TG. TG, lymphatic absorption of n-3 polyunsaturated fatty acids from marine oils with different intramolecular fatty acid distribution. Biochim. Biophys. Acta. 1994;1215:198–204
  28. Christensen MS, Høy C-E. Time related incorporation of (n 3) polyunsaturated fatty acids from seal oil or fish oil into rat tissue phospholipids. Nutr. Res. 1992;12:1141–1154
  29. Silverman DI, Ware JA, Sacks FM, Pasternak RC. Comparison of the absorption and effect on platelet function of a single dose of n-3 fatty acids given as fish or fish oil. Am.J. Clin. Nutr. 1991;53:1165–1170

☆ The main results have been previously published in the proceedings of a workshop at the 29th yearly meeting of The European Society for Clinical Investigation: n-3 Fatty acids: prevention and treatment in vascular disease. S.D. Kristensen, E.B. Schmidt, R. de Caterina, S. Endres (Eds). Springer Verlag, London, 1995

PII: S0952-3278(10)00117-1

doi: 10.1016/j.plefa.2010.06.007

Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume 83, Issue 3 , Pages 137-141 , September 2010

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