Prostaglandins, Leukotrienes and Essential Fatty Acids RSS feed: Articles in Press. The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes and Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease. To order this journal online, visit http://intl.elsevierhealth.com/journals/plef http://www.plefa.com//inpress?rss=yesElsevier Inc.en © 2012 Published by Elsevier Inc. Prostaglandins, Leukotrienes and Essential Fatty Acids0952-32782012-02-06 © 2012 Published by Elsevier Inc. healthpermissions@elsevier.comhttp://www.plefa.com/article/PIIS095232781200004X/abstract?rss=yesAbstract: The n-3 fatty acids, eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) regulate hepatic lipid and glucose metabolism; however, EPA and DHA are naturally present in human diets in foods of animal origin, which are generally high in protein with variable triglycerides and uniformly low amounts of carbohydrate. We used dietary information for 611 individuals of 1.5–66 years to address whether EPA and DHA are associated with protein, but not fat intake. EPA, DHA and arachidonic acid (20:4n-6) intakes were positively associated with protein, but not fat intake, whereas linoleic acid (18:2n-6) and α-linolenic acid (18:3n-3) intakes were positively associated with fat, but not protein intake. Children 1–3 years of age have lower EPA and DHA intakes than children over 4 years or adults. Recommendations regarding EPA and DHA intake should focus on protein sources, rather than diet fat, and consider their potential roles in amino acid and protein metabolism.Dietary long chain n-3 fatty acids are more closely associated with protein than energy intakes from fat - Corrected ProofE.M. Novak, S.M. Innis10.1016/j.plefa.2012.01.003Prostaglandins, Leukotrienes and Essential Fatty Acids (2012)2012-02-06Prostaglandins, Leukotrienes and Essential Fatty Acids2012-02-06http://www.plefa.com/article/PIIS0952327812000038/abstract?rss=yesAbstract: Fish consumption has shown its benefits for cognitive functioning in the elderly or children with disorders (e.g., autism, ADHD), but has rarely been investigated in relation to cognitive performance and school performance of healthy adolescents. We executed an observational study in 700 Dutch high school students aged 12–18 years. Fish consumption data, end term grades, scores on the Amsterdam Vocabulary Test, and scores on the Youth Self-Report were collected. Results revealed that 13.6% of the Dutch adolescents never ate fish, 6.4% met national guidelines, 16.9% reached half of the norm, and 63.1% did eat fish but too little to meet at least half of the norm. Analysis of variance, controlled for relevant covariates, showed significant differences between the four fish consumption groups in vocabulary (p=.05). A trend for significance was found for end term grades (p=.07). Contrast analyses demonstrated significant quadratic associations between fish consumption and vocabulary (p=.01) and end term grades (p=.01). Thus higher fish intake was associated with more advanced vocabulary and higher end term grades. However, eating more fish than the described norm seemed no longer beneficial.Eating the right amount of fish: Inverted U-shape association between fish consumption and cognitive performance and academic achievement in Dutch adolescents - Corrected ProofR.H.M. de Groot, C. Ouwehand, J. Jolles10.1016/j.plefa.2012.01.002Prostaglandins, Leukotrienes and Essential Fatty Acids (2012)2012-01-24Prostaglandins, Leukotrienes and Essential Fatty Acids2012-01-24http://www.plefa.com/article/PIIS095232781100189X/abstract?rss=yesAbstract: n-3 Polyunsaturated fatty acids (PUFA) are increasingly consumed as food additives and supplements; however, the side effects of these fatty acids, especially at high doses, remain unclear. We previously discovered a high fat n-3 PUFA diet made of fish/flaxseed oils promoted significant weight gain in C57BL/6 mice, relative to a control, without changes in food consumption. Therefore, here we tested the effects of feeding mice high fat (HF) and low fat (LF) n-3 PUFA diets, relative to a purified control diet (CD), on locomotor activity using metabolic cages. Relative to CD, the HF n-3 PUFA diet, but not the LF n-3 PUFA diet, dramatically reduced ambulatory, rearing, and running wheel activities. Furthermore, the HF n-3 PUFA diet lowered the respiratory exchange ratio. The data suggest mixed fish/flaxseed oil diets at high doses could exert some negative side effects and likely have limited therapeutic applications.High dose of an n-3 polyunsaturated fatty acid diet lowers activity of C57BL/6 mice - Corrected ProofBenjamin Drew Rockett, Mitchel Harris, Saame Raza Shaikh10.1016/j.plefa.2011.12.001Prostaglandins, Leukotrienes and Essential Fatty Acids (2011)2011-12-19Prostaglandins, Leukotrienes and Essential Fatty Acids2011-12-19SHORT COMMUNICATIONhttp://www.plefa.com/article/PIIS0952327810000803/abstract?rss=yesThis article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.WITHDRAWN: Prostaglandin E1 attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells - Corrected ProofWentong Fang, Hongjian Li, Liaosheng Zhou10.1016/j.plefa.2010.02.036Prostaglandins, Leukotrienes and Essential Fatty Acids (2010)2010-04-09Prostaglandins, Leukotrienes and Essential Fatty Acids2010-04-09