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Abstract
In order to determine the effects of dietary trans linoleate on the concentration
of PGF2α and its precursor acid, and on platelet aggregation, four groups of rats were fed
a diet containing hydrogenated coconut oil (HCO, treatment A); 9 trans, 12 trans linoleate
(trans linoleate, treatment B); an equal mixture of 9 cis linoleate (cis linoleate)
and trans linoleate (treatment C); and cis linoleate (treatment D); respectively for
12 weeks. The levels of arachidonic acid as a percent of total serum lipids were 5.8,
0.8, 25.2 and 30.0, respectively for treatments A, B, C, and D. The serum concentrations
of PGF2α were 3.2, 0.31, 14.1 and 27.4 ng/ml, respectively for treatments A, B, C, and D.
Thus, trans linoleate caused decreased biosynthesis of PGF2α probably resulting from decreased level of its precursor acid. The magnitude of the
inhibition of the platelet aggregation by indomethacin was greater in treatment A
than in treatment B. The difference in the magnitude of the inhibition between treatment
C and D was not apparent at a high concentration of indomethacin, however, at a lower
concentration (0.01 mM) the percent inhibition was 3 and 42 for treatments C and D,
respectively. These results indicate that levels of dietary linoleate can affect physiological
responses through an effect on the amount of PG synthesized in animal tissues.
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© 1978 Published by Elsevier Inc.
