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In order to determine the effects of dietary trans linoleate on the concentration of PGF2α and its precursor acid, and on platelet aggregation, four groups of rats were fed a diet containing hydrogenated coconut oil (HCO, treatment A); 9 trans, 12 trans linoleate (trans linoleate, treatment B); an equal mixture of 9 cis linoleate (cis linoleate) and trans linoleate (treatment C); and cis linoleate (treatment D); respectively for 12 weeks. The levels of arachidonic acid as a percent of total serum lipids were 5.8, 0.8, 25.2 and 30.0, respectively for treatments A, B, C, and D. The serum concentrations of PGF2α were 3.2, 0.31, 14.1 and 27.4 ng/ml, respectively for treatments A, B, C, and D. Thus, trans linoleate caused decreased biosynthesis of PGF2α probably resulting from decreased level of its precursor acid. The magnitude of the inhibition of the platelet aggregation by indomethacin was greater in treatment A than in treatment B. The difference in the magnitude of the inhibition between treatment C and D was not apparent at a high concentration of indomethacin, however, at a lower concentration (0.01 mM) the percent inhibition was 3 and 42 for treatments C and D, respectively. These results indicate that levels of dietary linoleate can affect physiological responses through an effect on the amount of PG synthesized in animal tissues.
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