Research Article| Volume 1, ISSUE 2, P159-164, August 1978

Prostaglandin El-induced potentiation of the anticonvulsant action of phenobarbitone in the rat. Role of brain monoamines.

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      Prostaglandin E1 (PGE1) significantly potentiated the anticonvulsant action of a sub-effective (ED0) dose of phenobarbitone, against maximal electroshock-induced seizures in the rat. PGE1-induced potentiation of phenobarbitone was significantly inhibited after pretreatment with drugs which are known to reduce brain serotonin activity, but was unaffected by drugs known to decrease brain catecholamine activity. Prostaglandin F2 alpha produced a moderate though statistically insignificant inhibition of PGEl effect. The results suggest that PGEI-induced potentiation of phenobarbitone is not a direct effect but an indirect one, mediated through an increase in brain serotonin activity.
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        • Coceani F.
        Prostaglandins and the central nervous system.
        Arch Int Med. 1974; 133: 119
        • Haubrich D.R.
        • Perez-Cruet J.
        • Reid W.D.
        Prostaglandin El causes sedation and increases 5-hydroxytryptamine turnover in rat brain.
        Brit J Pharmacol. 1973; 48: 80
        • Bhattacharya S.K.
        • Reddy P.K.S.P.
        • Debnath P.K.
        • Sanyal A.K.
        Potentiation of anticiceptive action of morphine by prostaglandin El in albino rats.
        Clin Exp Pharmacol Physiol. 1975; 2: 353
        • Bhattacharya S.K.
        • Mukhopadhyay S.N.
        • Debnath P.K.
        • Sanyal A.K.
        Role of 5-hydroxytryptamine in prostaglandin El-induced potentiation of hexobarbitone hypnosis in albino rats.
        Experientia. 1976; 32: 907
        • Bhattacharya S.K.
        • Sanyal A.K.
        Inhibition of pentylenetetrazol-induced convu Sions in rats by prostaglandin E1 role of brain monoamines.
        Psychopharmacology (Ber .). 1978; 56: 235
        • Sanyal A.K.
        • Bhattacharya S.K.
        • Keshary P.R.
        • Srivastava D.N.
        • Debnath P.K.
        Antinociceptive effect of prostaglandin El in the rat.
        Clin Exp Pharmacol Physiol. 1977; 4: 247
        • Poddubiak Z.
        • Kleinrok Z.
        The comparison of the central action of some prostaglandins in rats.
        in: Advances in Prostaglandin and Thromboxane Research. Vol 2. Raven Press, New York1976: 838
        • Meyer H.
        • Frey H.H.
        Dependence of anticonvulsant drug action on central monoamines.
        Neuropharmacology. 1973; 12: 939
      1. Bhattacharya SK, Bose R, Ghosh P. Anticonvulsant action of phenobarbitone in the rat. Role of brain monoamines. Materia Medica Polona (in Press)

        • Toman J.E.P.
        • Swinyard E.A.
        • Goodman L.S.
        Properties of maximal seizures and their alteration by anticonvulsant drugs and other agents.
        J Neurophysiol. 1946; 9: 231
        • Bhattacharya S.K.
        Studies on the role of brain monoamines in the pharmacological actions of some centrally acting drugs.
        in: Ph.D. dissertation. Banaras Hindu University, 1977
        • Holmes S.W.
        • Horton E.W.
        Prostaglandins and the central nervous system.
        in: Ramwell P.W. Shaw J.E. Prostaglandin Symposium of Worcestor Foundation for Experimental Biology. Interscience, New York1968: 21
        • Turner R.A.
        Screening Methods in Pharmacology. Vol 1. Academic Press, New York1965
        • Koe B.K.
        • Weissman A.
        p-Chlorophenylalanine a specific depletor of brain serotonin.
        J Pharmacol Exp Ther. 1966; 154: 499
        • Baumgarten H.G.
        • Bjorklund A.L.
        • Lachenmayer L.
        • Novin A.
        • Stenevi U.
        Long lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine.
        Acta Physiol Scand. 1971; 373 (Suppl): 1
        • Spector S.
        Inhibition of endogenous catecholamine biosynthesis.
        Pharmacol Rev. 1966; 18: 599
        • Carlsson A.
        • Lindqvist M.
        • Fuxe K.
        • Hokfelt T.
        Histochemical and biochemical effects of diethyldithiocarbamate on tissue catecholamines.
        J Pharm Pharmacol. 1966; 18: 60
      2. Srivastava DN, Bhattacharya SK, Sanyal AK. Effect of some prostaglandin synthesis inhibitors on the antinociceptive action of morphine in albino rats. Clin Exp Pharmacol Physiol (in press).

      3. Sanyal AK, Srivastava DN, Bhattacharya SK, The antinociceptive effect of intracerebroventricularly administered prostaglandin El in the rat. Psychopharmacology (Berl.), in press.

        • Debnath P.K.
        • Bhattacharya S.K.
        • Sanyal A.K.
        • Poddar M.K.
        • Ghosh J.J.
        Effect of prostaglandin El on brain, stomach and intestinal serotonin in rat.
        Biochem Pharmacol. 1978; 27: 130
        • Bhattacharya S.K.
        • Debnath P.K.
        • Sanyal A.K.
        Antagonism of some central pharmacological actions of prostaglandin El by prostaglandin F2alpha in rat.
        Ind J Med Res. 1978; 67: 848
        • Hedqvist P.
        Autonomic Neurotransmission.
        in: The Prostaglandins. Vol. 1. Plenum Press, New York1973: 101