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Abstract
A failure of thromboxane (TX) A2 synthesis may be a factor in cancer. Such a loss
could explain the susceptibility to mutation, the excess prostaglandin production,
the glycolytic mode of metabolism and the deranged calcium pumping characteristic
of cancers. Ionising radiation and phorbols both have actions similar to inhibitors
of TXA2 synthesis whereas colchicine and oxygen have actions consistent with stimulation
of TXA2 synthesis. The concept accounts logically for hitherto unexplained features
of cancer and suggests new strategies for the prevention and treatment of cancer.
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© 1978 Published by Elsevier Inc.