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Intradermal injections of 1–50 pmol leukotriene B4, C4, D4 and E4, (LTB4, LTC4, LTD4 and LTE4) were performed in healthy subjects and patients with recurrent urticaria. A wheal and erythema were seen 15 minutes after injection and were most marked after LTC4 and LTD4. LTE4 also produced a wheal whereas the reaction to LTB4 did not significantly differ from the saline control. When mixed with histamine no potentiation of the wheals was noted and no significant difference in reaction was observed between the healthy controls and those with urticaria.
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- Leukotrienes: A novel group of biologically active compounds.Vitamins and Hormones. 1982; 39: 1
- Effects of intradermally injected leukotriene C4 and histamine in patients with urticaria, psoriasis and atopic dermatitis.British Journal of Dermatology. 1982; 107: 106
- Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4.Journal of Investigative Dermatology. 1982; 78: 329
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© 1983 Published by Elsevier Inc.