Separation of the two components of the contractile activity of leukotriene C4 on the guinea pig lung parenchymal strip

F.J. Zijlstra; J.E. Vincent; I.L. Bonta

doi:10.1016/0262-1746(83)90091-4

Research Article| Volume 11, ISSUE 4, P385-389, August 1983

Separation of the two components of the contractile activity of leukotriene C₄ on the guinea pig lung parenchymal strip

F.J. Zijlstra
F.J. Zijlstra
Affiliations
Department of Pharmacology, Medical Faculty, Erasmus University Rotterdam, P.O.Box 1738, 3000 DR Rotterdam, The Netherlands
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J.E. Vincent
J.E. Vincent
Correspondence
reprint requests to JEV
Affiliations
Department of Pharmacology, Medical Faculty, Erasmus University Rotterdam, P.O.Box 1738, 3000 DR Rotterdam, The Netherlands
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I.L. Bonta
I.L. Bonta
Affiliations
Department of Pharmacology, Medical Faculty, Erasmus University Rotterdam, P.O.Box 1738, 3000 DR Rotterdam, The Netherlands
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DOI:https://doi.org/10.1016/0262-1746(83)90091-4

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Abstract

The contractions, induced by LTC₄ in the guinea pig lung parenchymal strip are composed of two parts, one of which is due to the effect of the released TxA₂ and the other one to the direct action of LTC₄. After the addition of indomethacin, the TxA₂ release is totally inhibited, but the contractions only partly. It is shown that the release of TxA₂ only occurs during the initial period of the contractions. This indicates that the direct action of LTC₄ represents the slow acting component in the contraction.

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DOI: https://doi.org/10.1016/0262-1746(83)90091-4

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