Research Article| Volume 11, ISSUE 4, P391-399, August 1983

A comparative study of PGI2 and two analogues (FCE 21292 and FCE 21258) in vitro and in vivo

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      Two analogues of PGI2, FCE 21258 (5E-13,14-didehydro-carboprostacyclin) and FCE 21292 (5E-13,14-didehydro-20-methyl-carboprostacyclin) have been evaluated in comparison with PGI2 in different Math Eq and Math Eq screening tests.
      The rank order of potency was PGI2 > FCE 21292 > FCE 21258 in the following tests: potentiation of bradykinin-induced increased plasma protein extravasation in the guinea pig skin, inhibition of guinea pig platelet aggregation Math Eq where the duration of action of FCE 21292 was longer than that of PGI2, lowering of mean systemic arterial pressure in conscious normotensive and spontaneously hypertensive rats and inhibition of rabbit platelet aggregation Math Eq.
      In the relaxation of bovine coronary artery Math Eq the rank order of potency was FCE 21292 > PGI2 > FCE 21258.
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