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Abstract
Two analogues of PGI2, FCE 21258 (5E-13,14-didehydro-carboprostacyclin) and FCE 21292 (5E-13,14-didehydro-20-methyl-carboprostacyclin)
have been evaluated in comparison with PGI2 in different
and
screening tests.


The rank order of potency was PGI2 > FCE 21292 > FCE 21258 in the following tests: potentiation of bradykinin-induced
increased plasma protein extravasation in the guinea pig skin, inhibition of guinea
pig platelet aggregation
where the duration of action of FCE 21292 was longer than that of PGI2, lowering of mean systemic arterial pressure in conscious normotensive and spontaneously
hypertensive rats and inhibition of rabbit platelet aggregation
.


In the relaxation of bovine coronary artery
the rank order of potency was FCE 21292 > PGI2 > FCE 21258.

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© 1983 Published by Elsevier Inc.