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Abstract
Thromboxane A2 has been implicated in thrombotic vascular diseases. The diabetic population has
a high incidence of vascular complications. In the present study, activity of thromboxane
synthetase in platelets of type 2 (non-insulin dependent) diabetic patients was studied.
Thromboxane synthesizing activity in diabetic platelets was significantly higher than
that in controls (p<0.05).
An effect of dietary arachidonic acid on thromboxane synthesizing activity in platelets
was also studied.Dietary arachidonic acid supplementation containing 1.7g of arachidonic
acid per day for 1 week caused a significant increase of arachidonic acid content
in plasma total lipids p < 0.05), but the increase of arachidonic acid in plasma total
lipids did not correlate with the level of arachidonic acid in platelet phospholipids.
Thromboxane synthesizing activity in platelets from the diabetics and the controls
was augmented by a diet enriched in arachidonic acid from 2. 20 ± 0. 15 to 2. 56 ±
0. 20 and from 1.71 ± 0. 23 to 2. 01 ± 0. 34, respectively. The increase in diabetic
subjects was statistically significant (p< 0.05). These results suggest that fatty
acids of dietary origin are important factors in development of thrombotic vascular
diseases.
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© 1983 Published by Elsevier Inc.
