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Abstract
The Prostacyclin(PGI2)-formation of the aortic vessel wall of normal and of atherosclerotic rabbits was
measured by punching out and incubating small pieces of the vessel wall. In atherosclerotic
rabbits the pieces taken from plaques produced more PGI2 than pieces taken from normal areas nearby. In addition, distinct differences were
seen between different regions of the aorta. An investigation in normal rabbits of
the regional distribution of the PGI2-producing capacity between the aortic valve and the bifurcation showed the highest
production at places where the earliest and most severe atherosclerotic changes were
observed in the atherosclerotic animals.
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References
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Article info
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© 1983 Published by Elsevier Inc.
