Research Article| Volume 11, ISSUE 4, P457-469, August 1983

Evaluation of antiarrhythmic activity of prostaglandin F in man

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      Since prostaglandin (PG) F had been shown to act antiarrhythmically in various animal models and also in preliminary investigations in man, further evaluation of this effect was made in 30 patients with cardiac extrasystoles and in 2 patients with tachycardias. PGF was infused intravenously at individually adapted consecutive rates from 5 to l00 μg/min each for at least 5 min. In the incidence of extrasystoles a mean maximum decrease of 41 % (P< 0.001) was obtained. One patient showed repeated short interruptions of a ventricular tachycardia. A dose-dependent significant rise in blood pressure and no significant influences on heart rate, PQ interval and QRS interval of the ECG were found. It is concluded that PGF has probably no practical importance for the therapy of cardiac arrhythmias.
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