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Abstract
Since prostaglandin (PG) F2α had been shown to act antiarrhythmically in various animal models and also in preliminary
investigations in man, further evaluation of this effect was made in 30 patients with
cardiac extrasystoles and in 2 patients with tachycardias. PGF2α was infused intravenously at individually adapted consecutive rates from 5 to l00
μg/min each for at least 5 min. In the incidence of extrasystoles a mean maximum decrease
of 41 % (P< 0.001) was obtained. One patient showed repeated short interruptions of
a ventricular tachycardia. A dose-dependent significant rise in blood pressure and
no significant influences on heart rate, PQ interval and QRS interval of the ECG were
found. It is concluded that PGF2α has probably no practical importance for the therapy of cardiac arrhythmias.
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© 1983 Published by Elsevier Inc.