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In two independent studies, ibuprofen and naproxen sodium were found to be equi-effective in alleviating dysmenorrheic symptoms. However, the effects of these drugs on menstrual PG release were found to be dissimilar. Ibuprofen primarily inhibited menstrual PGF2α release with little effect on PGE release, whereas, naproxen sodium inhibited both PGF2α and PGE2 release equally. To verify these results, we determined the inhibitory potency, IC 50' of ibuprofen and naproxen sodium on PGF2α and PGE2 synthesis in the rat uterine homogenate system. The preferential PGF2a inhibitory activity of ibuprofen was confirmed.
These findings suggest that ibuprofen may, in addition to inhibiting fatty acid cyclooxygenase, also inhibit PGF2α reductase, or some other PG metabolic pathways which affect PGF a and PGE2 synthesis differently. The significance of this differential PG synthesis inhibitory effect in dysmenorrheic therapy is discussed.
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- Prostaglandin inhibitors and antagonists in dysmenorrhea therapy.in: Dawood M.Y. Dysmenorrhea. Williams and Wilkins, Baltimore1981: 209
- Prostaglandin synthetase inhibitors and dysmenorrhea. A survey and personal clinical experience.Acta Obstetricia et Gynecologica Scandinavica Supplement. 1979; 87: 73
- New concepts in dysmenorrhea.American Journal of Obstetrics and Gynecology. 1978; 130: 833
- Inhibition of prostaglandin biosynthesis as the mechanism of action of aspirin-like drugs.Advances in Biosciences. 1973; 9: 395
- Prostaglandins in primary dysmenorrhea, comparison of prophylactic and nonprophylactic treatment with ibuprofen and the use of oral contraceptives.American Journal of Medicine. 1981; 70: 535
- Effects of naproxen sodium on menstrual prostaglandins and primary dysmenorrhea.Obstetrics and Gynecology. 1983; 61: 285
- Determination of menstrual prostaglandin levels in non-dysmenorrheic and dysmenorrheic subjects.Prostaglandins. 1978; 15: 365
- A sensitive method for the assay of 5-hydroxytryptamine.British Journal of Pharmacology. 1957; 12: 344
- Prostaglandin and thromboxane production by the rat uterus and ovary in vitro during the oestrous cycle.Journals of Reproduction & Fertility. 1980; 60: 33
- Prostaglandins and aspirin-like drugs.Hospital Practice. 1972; 7: 61
- The role of copper in prostaglandin synthesis.Biochemica et Biophysica Acta. 1973; 306: 74
- Evidence for two distinct forms of fatty acid cyclooxygenase in brain.Journal of Neurochemistry. 1982; 38: 1111
- Effects of the prostaglandins on the uterus. Prostaglandins and uterine contractility.Acta Obstetricia et Gynecologica Scandinavica Supplement. 1979; 87: 33
☆This work was supported by research grants from NICHHD (HD-13064) and the NIGMS (GM-07547).
© 1984 Published by Elsevier Inc.