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Abstract
Tritium-labelled ZK 36 374 was administered to three female beagle dogs intravenously
and orally in a dose of 200 μg/kg. Blood and plasma levels and excretion with urine
and feces of drug and metabolites were measured. ZK 36 374 was rapidly absorbed. The
bioavailability was estimated as about 10 % of the dose. The concentration of radio-labelled
compounds in the plasma declined in three phases with half-lives of 3 min, 46 min
and approx. 2 d. The half-life of the unchanged drug was 14 min. ZK 36 374 was totally
metabolized and excreted mainly via the kidneys.
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References
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© 1984 Published by Elsevier Inc.
