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Abstract
Prostaglandin E2 (PGE2)-like activity was measured in osteonecrotic femoral heads caused by high doses of
methyl prednisolone acetate in rabbits. Serum levels of cholesterol, total lipids,
free fatty acids, alkaline phosphatase, SGOT and lipase were also determined. There
were increases in local tissue PGE2-like activity, serum cholesterol, total lipid and free fatty acid levels in rabbits
with steroid-induced osteonecrosis as compared to the controls. The rabbits given
aprotinin together with the steroid showed significant decreases in serum cholesterol
and lipid levels coupled with a marked increase in the local PGE2-like activity. Aprotinin prevented osteonecros is induced by steroids. The results
are discussed in the light of the relevant literature.
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© 1984 Published by Elsevier Inc.