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Abstract
Aqueous extracts of onion, garlic and ginger were found to inhibit aggregation induced
by ADP, epinephrine, collagen and arachidonate in a dose-dependent manner ![Math Eq]()
. In the case of onion and garlic extracts relatively much higher volumes were need
to bring about even a modest inhibition (by ca. 13–18%) of thromboxane synthesis in
washed platelets from labelled AA. On the other hand a good correlation was found
between the amounts of ginger extract needed to inhibit platelet aggregation and those
to inhibit platelet thromboxane synthesis. Ginger extract reduced also platelet prostaglandin-endoperoxides.
A dose-related inhibition of platelet thromboxane- and prostaglandin (PGF2α, PGE2 and PGD2) synthesis was affected by ginger extract. Extracts of onion, garlic and ginger inhibited
biosynthesis of prostacyclin in rat aorta from labelled AA. Ginger extract mildly
inhibited the synthesis of prostacyclin from endogenous pool of AA in rat aorta; the
other two extracts were without effect.
. In the case of onion and garlic extracts relatively much higher volumes were need
to bring about even a modest inhibition (by ca. 13–18%) of thromboxane synthesis in
washed platelets from labelled AA. On the other hand a good correlation was found
between the amounts of ginger extract needed to inhibit platelet aggregation and those
to inhibit platelet thromboxane synthesis. Ginger extract reduced also platelet prostaglandin-endoperoxides.
A dose-related inhibition of platelet thromboxane- and prostaglandin (PGF2α, PGE2 and PGD2) synthesis was affected by ginger extract. Extracts of onion, garlic and ginger inhibited
biosynthesis of prostacyclin in rat aorta from labelled AA. Ginger extract mildly
inhibited the synthesis of prostacyclin from endogenous pool of AA in rat aorta; the
other two extracts were without effect.To read this article in full you will need to make a payment
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References
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![Math Eq]()
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. - Altered arachidonic acid metabolism in platelets inhibited by onion or garlic extracts.in: Samuelsson B. Ramwell P.W. Paoletti R. Advances in Prostaglandin and Thromboxane Research. Volume 6. Raven Press, New York1980: 309
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Copyright
© 1984 Published by Elsevier Inc.
