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Abstract
The incidence of vascular disorders increases with age, and is also higher in men
than in women.Since prostaglandin (PG)I2 produced by blood vessels has been proposed to have a protective function in the
cardiovascular system, reduced vascular PGI2 production with age and lower vascular PGI2 production in males than in females may be causes for these increases in the incidence
of vascular disorders.The production of prostaglandins by blood vessels has therefore
been investigated in young (2 to 3 months) and old (12 to 14 months), male and female
rats.
The amounts of 6-keto-PGF1α (reflecting PGI2 formation) synthesized by endothelial cell suspensions were significantly lower in
old compared to young male rats, but did not differ between old and young female rats.
The amounts of 6-keto-PGF1α synthesized by homogenates of aortic smooth muscle were considerably higher in old
compared to young, male and female rats.However, the basal output of 6-keto-PGF1α from the perfused aorta ![Math Eq]()
did not change significantly with increase in age and, if anything, tended to be
higher in the older rats, of both sexes. Furthermore, the basal output of 6-keto-PGF1α from the aorta was significantly higher in young and old, male rats compared to young
and old, female rats, respectively.Similar findings were observed regarding basal
6-keto-PGF1α output from the perfused mesenteric arterial bed in vitro.The increases in output
of 6-keto-PGF1α from the mesenteric arterial bed in response to noradrenaline and angiotensin II
were not diminished with age in either male or female rats. Consequently, PGI2 output from the blood vessels studied did not decrease with age, nor was it lower
in male rats compared to female rats.
did not change significantly with increase in age and, if anything, tended to be
higher in the older rats, of both sexes. Furthermore, the basal output of 6-keto-PGF1α from the aorta was significantly higher in young and old, male rats compared to young
and old, female rats, respectively.Similar findings were observed regarding basal
6-keto-PGF1α output from the perfused mesenteric arterial bed in vitro.The increases in output
of 6-keto-PGF1α from the mesenteric arterial bed in response to noradrenaline and angiotensin II
were not diminished with age in either male or female rats. Consequently, PGI2 output from the blood vessels studied did not decrease with age, nor was it lower
in male rats compared to female rats.The blood pressure was significantly higher in the old rats compared to the young
rats.Also, the vascular output of PGF2α, a vasoconstrictor, was higher in the old rats.The increase in blood pressure with
age may therefore be connected with this increase in vascular PGF2α production in both sexes.
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© 1986 Published by Elsevier Inc.
