Research Article| Volume 25, ISSUE 1, P27-29, November 1986

The effect of etretinate, a synthetic retinoid, on pancreatic prostaglandin production

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      Prostaglandin E2 levels in hamster pancreas were measured by radioimmunoassay. Control animals (N = 22) were compared to etretinate treated animals (N = 33). There was a highly significant reduction in pancreatic prostaglandin E2 production in the treated animals (means 1.842 ng/mg pancreas and 0.486, p <0.0005) suggesting that etretinate is a blocker of pancreatic prostaglandin production.
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        • Goodwin J.S.
        • Husby G.
        • Williams J.R.C.
        Prostaglandin E and cancer growth.
        Cancer, Immunol Immunother. 1980; 8: 3
        • Decosse J.J.
        Potential for chemoprevention.
        Cancer. 1982; 50 (Supplement 2550)
        • Cornwall A.
        • Odukoya D.
        • Shklar G.
        Oral mucosal tumour inhibition by Ibuprofen.
        Oral Maxillofac Surg. 1983; 41: 795
        • Ziboh V.A.
        • Price B.
        • Fulton J.
        Effects of retinoic acid on prostaglandin biosynthesis in guinea-pig skin.
        J Invest Dermatol. 1975; 65: 370
        • Wong E.
        • Barr R.M.
        • Blain S.D.
        • Olins L.A.
        • Greaves M.W.
        The effect of etretinate on cyclo-oxygenase and lipoxygenase products of arachidonic acid in psoriatic skin.
        Br J Dermatology. 1983; 109: 703
        • Brincker Hoff C.E.
        • McMillan R.M.
        • Dayer J.M.
        • Harris Jr., E.D.
        Inhibition by retinoic acid of collagenase production in rheumatoid synovial cells.
        N Engl J Med. 1980; 303: 432
        • Kingston W.P.
        • Sunderland U.K.
        The antipsoriatic agents retinoic acid and etretinate inhibit 15 lipoxygenase.
        Clinical Science. 1984; 67: 221
        • Sircar J.C.
        • Schwerder C.F.
        Antipsoriatic drugs as inhibitors of soybean lipoxygenase. A possible mode of action.
        Prostaglandins, Leukotrienes and Med. 1983; 11: 373
        • Brandes D.
        Re-expression of cellular retinoic acid binding protein in human and hampster pancreatic carcinoma.
        in: Proceedings of the First International Conference on the modu lation and mediation of cancer by vitamins. Karger, Basel1983
        • Kontarek S.J.
        • Tasler J.
        • Jawolek J.
        • et al.
        Prostacyclin inhibits pancreatic secretion.
        J Physiol. 1980; 238: 531
        • Glazer G.
        • Bennett A.
        Prostaglandin release in canine acute haemorrhagic pancreatitis.
        Gut. 1975; 17: 22