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Abstract
Earlier studies have demonstrated an age dependent effect in the extent of sudanophilic
and atherosclerotic lesions around aortic ostia in men. As prostacyclin may be a key
determinant in the development of atherosclerosis we examined its formation around
abdominal aortic ostia (coeliac, superior mesenteric and inferior mesenteric arteries)
in-vitro. Prostacyclin formation was higher distal to the orifice as compared to proximal
areas, but without reaching the level of significance. Prostacyclin formation was
always higher in females than in males and in non-smokers than in smokers, showing
the greatest difference distal to the ostium, but again without significance. From
the limited number of vessels examined, no trend for an age dependency can be noted.
The relation between prostacyclin generation and morphological data is discussed.
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© 1986 Published by Elsevier Inc.