Advertisement
Research Article| Volume 25, ISSUE 1, P65-70, November 1986

Antihypertensive effect of dietary sunflowerseed oil and linseed oil in spontaneously hypertensive rats during a multigeneration feeding study

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Semisynthetic diets enriched with polyunsaturated fatty acids (30 en% sunflowerseed oil or linseed oil) reduced hypertension development in spontaneously hypertensive rats (SHR) compared with control SHR fed on a regular rat chow. The effect was most markedly expressed in the 3rd and 4th generations of a four generation feeding period. PGI2-like production from isolated, pulsatingly perfused aorta preparations was reduced in linseed oil but not in sunflowerseed oil fed rats. Effects on blood pressure and PGI2-like production were abolished when the semisynthetic diets were changed for regular chow (5th and 6th generations).
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Prostaglandins, Leukotrienes and Essential Fatty Acids
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Schoene N.W.
        • Reeves U.B.
        • Ferretti A.
        Samuelsson B. Rammwell P.W. Paoletti R. Advances in Prostaglandin and Thromboxane Research. Vol 8. Raven Press, New York1980: 1791
        • Ezra D.
        • Bayorh M.A.
        • Zukowska-Grojec Z.
        • Lazar J.D.
        • Kopin I.J.
        • Feuerstein G.
        Clin Exper Hypert A. 1983; 5: 485
        • Hoffmann P.
        • Förster W.
        • Markov Ch.M.
        Prostagl Leukotr Med. 1982; 8: 151
        • Hoffmann P.
        • Taube Ch.
        • Heinroth-Hoffmann I.
        • Fahr A.
        • Beitz J.
        • Förster W.
        • Poleshuk W.S.
        • Markov Ch.M.
        Arch Internat Pharmacodyn. 1985; 276: 222
        • Somova L.
        • Hoffmann P.
        • Förster W.
        Eur J Pharmacol. 1980; 64: 79
        • Lockette W.E.
        • Webb R.C.
        • Culp B.R.
        • Pitt B.
        Prostaglandins. 1982; 24: 631
        • Schölkens B.A.
        • Gehring D.
        • Schlotte U.
        • Weithman U.
        Prostagl Leukotr Med. 1982; 8: 273
        • Pace-Asciak C.R.
        • Carrara M.C.
        • Rangaraj G.
        • Niolaou K.C.
        Prostaglandins. 1978; 15: 1005
        • Bohta J.H.
        • Leary W.P.
        • Asmal A.C.
        Prostaglandins. 1980; 19: 285
        • Quadt J.F.A.
        • Voss R.
        • ten Hoor F.
        J Pharmacol Methods. 1982; 7: 263
        • Taube Ch.
        • Hoffmann P.
        • Förster W.
        Prostagl Leukotr Med. 1982; 9: 411
        • Scherhag R.
        • Kramer H.H.
        • Düsing R.
        Prostaglandins. 1982; 23: 369
        • Sprengler U.
        • Lorenz R.
        • Weber P.C.
        Internat Prostagl Conf, Florence1982: 696 (Abstract)
        • Singer P.
        • Jaeger W.
        • Wirth N.
        • Voight S.
        • Naumann E.
        • Zimontkowski S.
        • Hajdn J.
        • Goedicke W.
        Atherosclerosis. 1983; 49: 99
        • Dyerberg J.
        Herman A.G Vanhoutte P.M. Denolin H. Goossens A. Cardiovascular Pharmacology of the Prostaglandins. Raven Press, New York1982: 233
        • Hornstra S.
        • Christ-Hazelhof E.
        • Haddeman E.
        • ten Hoor F.
        • Nugteren D.F.
        Prostaglandins. 1981; 21: 727
        • Willis A.L.
        Nutr Rev. 1981; 39: 289
        • Fischer S.
        • Weber P.C.
        Biochem Biophys Res Comm. 1983; 116: 1091
        • Fischer S.
        • Weber P.C.
        Nature. 1984; 307: 165