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Abstract
In acute experiments eleven nonpregnant women received a single oral dose of enprostil
(prostaglandin E2 analogue) 35–140 mcg. Uterine activity was measured by a microtransducer-tipped Millar
catheter. A single, oral dose of enprostil caused a longlasting contracture response
of the uterus. 3 h after enprostil, uterine resting pressure (RP) was still high.
In chronic experiments, eleven women with regular menstrual cycles received 35 mcg
or 70 mcg BID enprostil and placebo in a crossover, double-blind fashion from cycle
day 10 ± 3 for four weeks, then had a washout period of four weeks followed by another
four-week treatment period. An increase of uterine RP after enprostil was dose-dependent.
After two weeks of twice-daily administration of enprostil, the baseline RP was lower
than after placebo (p < 0.01) and the increase in RP after the morning enprostil less
than that seen on the first day. In eight patients studied, the mean values of plasma
progesterone were normal, both during placebo — and enprostil — treated cycles.
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References
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© 1989 Published by Elsevier Inc.
