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Research Article| Volume 36, ISSUE 1, P21-24, April 1989

Heparin inhibits the “quasi-lipoxygenase” activity of hemoglobin toward linoleic acid by oxidant scavenging

  • EP Brestel
    Correspondence
    Address reprint requests to EB whose current address is: Department of Medicine East Carolina University School of Medicine Greenville, NC 27858-4354, U.S.A.
    Affiliations
    Department of Medicine, West Virginia, University School of Medicine, Morgantown, WV 26506 USA.

    Department of Microbiology, West Virginia, University School of Medicine, Morgantown, WV 26506 USA.
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  • MT Koes
    Affiliations
    Department of Medicine, West Virginia, University School of Medicine, Morgantown, WV 26506 USA.

    Department of Microbiology, West Virginia, University School of Medicine, Morgantown, WV 26506 USA.
    Search for articles by this author
DOI:https://doi.org/10.1016/0952-3278(89)90157-9
Heparin inhibits the “quasi-lipoxygenase” activity of hemoglobin toward linoleic acid by oxidant scavenging
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      Abstract

      Previous studies have shown heparin to have antiinflammatory properties. We have attempted to determine if the mechanism involves the inhibition of lipid oxidation by utilizing a model system where linoleic acid is oxidized in the presence of oxygen and methemoglobin. Heparin inhibits this “quasi-lipoxygenase” activity prolonging the lag phase and slowing the rate of lipid peroxidation. An oxidant scavenging mechanism is also inferred from the fact that heparin is capable of inhibiting luminol-dependent chemiluminescence resulting from the reduction of 15-HPETE by methemoglobin. It is concluded that heparin, in at least this model system, is capable of inhibiting lipoxygenation by an oxidant scavenging mechanism.
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      Article info

      Identification

      DOI: https://doi.org/10.1016/0952-3278(89)90157-9

      Copyright

      © 1989 Published by Elsevier Inc.

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