Research Article| Volume 36, ISSUE 1, P25-29, April 1989

Influences of estradiol and of catechol and non-catechol estrogens on the output of prostaglandins in uteri from spayed rats

  • A.M. Franchi
    Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas de la República Argentina (CONICET) Argentina
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  • A.L. Gimeno
    Reprints requests and mailing address: ALG, Serrano 665, (1414) Buenos Aires, Argentina.
    Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas de la República Argentina (CONICET) Argentina

    Departmento de Farmacologia y Toxicologia, Facultad de medicina, Universidad de Buenos Aires Argentina
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  • M.A.F. Gimeno
    Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas de la República Argentina (CONICET) Argentina
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      The effects of 17-beta estradiol and of some catechol and non-catecholestrogens on the synthesis and output of prostaglandins (PGs) E and F by uteri from ovariectomized rats, were explored. Uteri from castrated animals released twice as much PGE than PGF. When uterine tissue was obtained from spayed rats injected prior to sacrifice with a low dose of 17-beta estradiol (0.5 ± 1.0 μg, on two consecutive days), the output of PGE diminished significantly. With a higher dose of the hormone (0.5 + 50.0 μg) the depressive influence on the synthesis and release of PGE was even more marked, whereas the output of PGF rose significantly. Low or high doses of estrone or of estriol failed to affect the release of either one of the PGs determined. On the other hand, 20H-estradiol at a low dose had no action but at a higher one inhibited the release of PGE without influencing PGF. Neither low nor high doses of 2-0H estriol or of 2-0H estrone affected the synthesis and release of uterine PGs. It was also observed that all the compounds tested evoked a significant uterotrophic action. It appears plausible that some catechol metabolites of 17-beta estradiol, but not other catechol-estrogens, could be involved in the mechanism of action of 17-beta estradiol modulating the production of PGs by the rat uterus.
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