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Abstract
The effects of 17-beta estradiol and of some catechol and non-catecholestrogens on
the synthesis and output of prostaglandins (PGs) E and F by uteri from ovariectomized
rats, were explored. Uteri from castrated animals released twice as much PGE than
PGF. When uterine tissue was obtained from spayed rats injected prior to sacrifice
with a low dose of 17-beta estradiol (0.5 ± 1.0 μg, on two consecutive days), the
output of PGE diminished significantly. With a higher dose of the hormone (0.5 + 50.0
μg) the depressive influence on the synthesis and release of PGE was even more marked,
whereas the output of PGF rose significantly. Low or high doses of estrone or of estriol
failed to affect the release of either one of the PGs determined. On the other hand,
20H-estradiol at a low dose had no action but at a higher one inhibited the release
of PGE without influencing PGF. Neither low nor high doses of 2-0H estriol or of 2-0H
estrone affected the synthesis and release of uterine PGs. It was also observed that
all the compounds tested evoked a significant uterotrophic action. It appears plausible
that some catechol metabolites of 17-beta estradiol, but not other catechol-estrogens,
could be involved in the mechanism of action of 17-beta estradiol modulating the production
of PGs by the rat uterus.
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© 1989 Published by Elsevier Inc.
