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Abstract
The antihypertensive activity of RS-93427, a synthetic prostanoid, was evaluated in
conscious restrained spontaneously hypertensive rats. RS-93427 possesses potent antihypertensive
activity when administered orally, intraduodenally, intravenously, or subcutaneously
but not topically. The blood pressure reducing activity of RS-93427 in normotensive
rats was comparable to that in hypertensive animals. No signs of tolerance to the
antihypertensive effects were observed following fourteen days of oral administration
of RS-93427. The synthetic prostanoid minimally enhanced the orthostatic hypotensive
responsiveness to vertical, head up. repositioning of the restrained rats. The relative
usefulness of the platelet antiaggregatory and antihypertensive properties of RS-93427
will have to be determined by clinical studies.
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prostaglandin E2 methylester (CL115, 347) a new orally and transdermally long-acting antihypertensive agent.Article info
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© 1989 Published by Elsevier Inc.
