Research Article| Volume 36, ISSUE 1, P35-41, April 1989

The antihypertensive properties of a synthetic prostanoid: RS-93427

  • M.B. Wallach
    Reprint requests to MBW, Scientific Information Department, Syntex Research, 3401 Hillview Avenue, Palo Alto, CA 94304 USA
    Department of Neuropharmacology, Syntex Research, 3401 Hillview Avenue, Palo Alto, CA 94304 USA
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      The antihypertensive activity of RS-93427, a synthetic prostanoid, was evaluated in conscious restrained spontaneously hypertensive rats. RS-93427 possesses potent antihypertensive activity when administered orally, intraduodenally, intravenously, or subcutaneously but not topically. The blood pressure reducing activity of RS-93427 in normotensive rats was comparable to that in hypertensive animals. No signs of tolerance to the antihypertensive effects were observed following fourteen days of oral administration of RS-93427. The synthetic prostanoid minimally enhanced the orthostatic hypotensive responsiveness to vertical, head up. repositioning of the restrained rats. The relative usefulness of the platelet antiaggregatory and antihypertensive properties of RS-93427 will have to be determined by clinical studies.
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