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Abstract
In this study we examined the effects of an orally active leukotriene (LT) antagonist
YM-16638 [[5-[[3-(4-acetyl-3-hydroxy- 2-propyl-phenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio]
acetic acid on antigen-induced early and late responses in allergic sheep. For all
studies YM-16638 was administered via intragastric tube 1 h before airway challenge
with Ascaris suum antigen. Six allergic sheep were challenged on four occassions (2 control and 2 drug
trials) earch ≥14 days apart and the tests were conducted in the following order:
control-1; YM-16638 30 mg/kg; control-2; YM-16638 10 mg/kg. Specific lung resistance
(SRL) was used as an index of the airway response to antigen and was measured before and
serially after antigen challenge. In both control trials antigen challenge resulted
in significant early and late airway responses (i.e. increases in SRL); however, there was a significant difference between the peak late increases of
SRL in control-1 (206%) and control-2 (115%) suggesting a carry-over effect of the 30
mg/kg dose of YM-16638. At both doses, YM-16638 reduced the early response and blocked
the late response when compared to either control trial. These results suggest that
sulfidopeptide LTs contribute to both antigen-induced early and late airway responses
in allergic sheep.
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References
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antagonist, LY171883, on antigen-induced airway responses in allergic sheep.Article info
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© 1989 Published by Elsevier Inc.
