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Abstract
Effects of prostacyclin and carbacyclins on endothelin-induced DNA synthesis were
investigated in vascular smooth muscle cells. DNA synthesis was estimated by [3H]thymidine incorporation. Five carbacyclins used in this report were 5-{(1S, 5S, 6R, 7R)-7-hydroxy-6-[(E)-(S)-3-hydroxy-1-octenyl]bicyclo[3.3.0]oct-2-en-3-yl}pentanoic acid (TEI-7165), methyl
5-{(1S, 5S, 6R, 7R)-7-hydroxy-6-[(E)-(S)-3-hydroxy-1-octenyl]bicyclo[3.3.0]oct-2-en-3-yl}pentanoate (TEI-9090), 5-{(1S, 5S, 6R, 7R)-7-hydroxy-6-[(E)-(3S, 5S)-3-hydroxy-5-methyl-1-nonenyl]bicyclo[3.3.0]oct-2-en-3-yl}pentanoic acid (TEI-9063),
methyl 5-{(1S, 5S, 6R, 7R)-7-hydroxy-6-[(E)-(3S, 5S)-3-hydroxy-5-methyl-1-nonenyl]bicyclo[3.3.0]oct-2-en-3-yl}pentanoate (TEI-1324),
5-{(1S, 5S, 6R, 7R)-7-hydroxy-6-[(E)-(S)-4-hydroxy-4-methyl-1-octenyl]bicyclo[3.3.0]oct-2-en-3-yl}pentanoic acid (TEI-3356).
Prostacyclin and the carbacyclins inhibited the endothelin-induced DNA synthesis within
the nanomolar range. These results suggest that prostacyclin and carbacyclins are
possibly effective in inhibiting the proliferation of vascular smooth muscle cells
under some situations in vivo.
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Article info
Publication history
Accepted:
July 4,
1991
Received:
April 4,
1991
Identification
Copyright
© 1991 Published by Elsevier Inc.
