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The influence of linoleic acid upon the sedimentation of washed erythrocytes from multiple sclerosis patients and controls was investigated in the present study. Linoleic acid, especially in the concentration of 250 μM and 500 μM, caused slowing of erythrocyte sedimentation and this effect was significantly greater in multiple sclerosis than in controls. These findings with all probability reflect an unsaturated fatty acid-dependent membrane alteration in multiple sclerosis and are analogous to results obtained earlier by several authors by using cytopherometric measurements.
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Accepted: July 3, 1991
Received: May 2, 1991
© 1991 Published by Elsevier Inc.